N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER synthesis
- Product Name:N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
- CAS Number:81167-39-7
- Molecular formula:C16H15NO2
- Molecular Weight:253.3
Yield: 70%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in acetonitrile at 90; for 12 h;
Steps:
501
FIG. 5 shows an example of a process for synthesizing 1-(4-ethyl-8-methyl-7,8,9a,10-tetrahydropyrido[1,2-α]indole-6,9-dione). Step 501. A solution of methyl bromoacetate (5.5 g, 35.9 mmol) in acetonitrile (40 mL) was treated with benzophenonimine (6.5 g, 35.8 mmol) and diisopropylethylamine (6.2 mL, 4.6 g, 35.6 mmol). The resulted mixture was heated at reflux (90° C.) for 12 hours. After reaction completion, the mixture was cooled to room temperature and concentrated in vacuo. The formed residue was partitioned between water (40 mL) and diethyl ether (60 mL), and the organic portion was separated, dried over MgSO4, filtered, and concentrated in vacuo. The product was purified by flash column chromatography and eluted with ethyl acetate/hexane to obtain white crystals (70%).
References:
Texas Tech University System;German, Nadezhda;Hossain, Modammad Anwar US2020/131183, 2020, A1 Location in patent:Paragraph 0046
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