Azidoacetic acid methyl ester synthesis
- Product Name:Azidoacetic acid methyl ester
- CAS Number:1816-92-8
- Molecular formula:C3H5N3O2
- Molecular Weight:115.0907
96-32-2
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1816-92-8
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Yield:1816-92-8 97%
Reaction Conditions:
with sodium azide in N,N-dimethyl-formamide for 8 h;Inert atmosphere;Reflux;
Steps:
Representative procedure for preparation of alkyl azide 2a:
General procedure: To a stirred solutionof heptylbromid (3.58 g, 20.0 mmol) in N,N-dimethylformamide (40.0 mL) was addedNaN3 (3.90 g, 60.0 mmol). Then the reaction mixture was warmed to 75 °C andrefluxed for 8 h, then cooled to room temperature and quenched with water (10 mL).The mixture was extracted with ethyl acetate (50 mL * 3), and the combined organicphase was washed with water (50 mL * 4) and brine (50 mL), dried over Na2SO4 andthen it was concentrated to afford 2a.
References:
Yu, Chun-Jiao;Li, Rui;Gu, Peiming [Tetrahedron Letters,2016,vol. 57,# 31,p. 3568 - 3570] Location in patent:supporting information
96-34-4
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1816-92-8
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$15.00/1g
5680-79-5
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1816-92-8
78 suppliers
$15.00/1g
