ChemicalBook CAS DataBase List Glycine methyl ester hydrochloride

Glycine methyl ester hydrochloride synthesis

12synthesis methods

Product Name:Glycine methyl ester hydrochloride
CAS Number:5680-79-5
Molecular formula:C3H8ClNO2
Molecular Weight:125.55

67-56-1 Synthesis

67-56-1
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$9.00/25ml

56-40-6 Synthesis

56-40-6
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$5.00/25g

5680-79-5
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$3.66/25g

Yield:5680-79-5 100%

Reaction Conditions:

Stage #1: methanolwith dichloro sulfoxide for 1 h;Cooling with ice;
Stage #2: 2-aminoacetic acid at 20 - 66; for 6.5 h;

Steps:

18.2 (2)
Preparation of glycine methyl ester hydrochloride

(2)
Preparation of glycine methyl ester hydrochloride
Under ice bath, 100 ml round-bottom flask was added with 60 ml of methanol, and then slowly added with 4 ml of SOCl₂ through constant pressure dropping funnel (with a drying tube on the top), and NaOH solution was used to absorb exhaust.
After stirring for 1 h, 8 mmol of glycine was added and stirred at room temperature for 30 min, and then refluxed at 66° C. for 6 h.
The reaction was tracked by TLC until the raw materials disappeared, with a solution of 2% ninhydrin in ethanol as chromogenic reagent.
The solvent was evaporated out to obtain glycine methyl ester hydrochloride. Yield: 100%.

References:

US2014/206741,2014,A1 Location in patent:Paragraph 0131