Mefenpyr-diethyl synthesis
- Product Name:Mefenpyr-diethyl
- CAS Number:135590-91-9
- Molecular formula:C16H18Cl2N2O4
- Molecular Weight:373.23
![Acetic acid, 2-[2-(2,4-dichlorophenyl)hydrazinylidene]-, ethyl ester](/CAS/20210305/GIF/1016169-48-4.gif)
Yield:135590-91-9 78%
Reaction Conditions:
with tert.-butylhydroperoxide;iodine in water;N,N-dimethyl-formamide at 80; for 4 h;Temperature;Reagent/catalyst;Solvent;
Steps:
3-10 synthesis of mefenpyr
ethyl 2-[2-(2,4-dichlorophenyl)hydrazin-1-ylidene]acetate (13.0 g, 0.05 mol) and ethyl methacrylate (6.8 g, 0.06 mol) were added to a 250 mL eggplant bottle. Add DMF (80 mL) to dissolve and dissolve, then add molecular iodine (12.6 g, 0.05 mol) and 70% aqueous solution of TBHP (12.8 g, 0.1 mol) to the reaction system, react at 80 ° C for 4 h, complete the reaction, add 100 ml of 10% aqueous sodium hydrogen sulfite solution. It was extracted with ethyl acetate (100 mL × 3), and the ethyl acetate layer was washed with brine (100 mL × 2)The petroleum ether was recrystallized to obtain 14.5 g of pyrazole oxalate, and the yield was 78%.
References:
CN110003107,2019,A Location in patent:Paragraph 0024; 0045-0068
![ethyl chloro[(2,4-dichlorophenyl)hydrazono]acetate](/CAS/20180711/GIF/27143-12-0.gif)
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135590-91-9
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