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ChemicalBook CAS DataBase List Ethyl ethoxyacetate
817-95-8

Ethyl ethoxyacetate synthesis

14synthesis methods
-

Yield:817-95-8 78%

Reaction Conditions:

with sulfuric acid at 100; for 2 h;Inert atmosphere;

Steps:

171.a Preparation of 2-ethoxyethyl acetate
Is set to have a 2-ethoxyacetic acid (20g, 0.19mol) in ethanol (200 mL) was added sulfuric acid (10mL). The resultant reactionmixture was reacted at 100 degrees for two hours. After completion of the reaction, the reaction solution was diluted with ethylacetate and after concentrating, the organic phase was washed twice with water, dried over anhydrous sodium sulfate andconcentrated to a yellow oily liquid (19.5g, 78%).

References:

MEDSHINEDISCOVERY INC.;CHENXIN PHARMACEUTICAL LTD;Zheng, Huiping;Wu, Chengde;Yu, Tao;Huang, Lei;Hao, Dongling;Gao, Bo;Sun, Jikui;Shi, Nengyang;Chen, Shuhui TW2016/2107, 2016, A Location in patent:Paragraph 0106; 0107

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