ChemicalBook CAS DataBase List Ethyl phenylacetate

Ethyl phenylacetate synthesis

12synthesis methods

Product Name:Ethyl phenylacetate
CAS Number:101-97-3
Molecular formula:C10H12O2
Molecular Weight:164.2

Ethyl phenylacetate is prepared by heating at the boil phenylacetonitrile and sulfuric acid in alcohol solution; by esterification of the acid catalyzed by HCl or H2SO4.

103-79-7
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$28.00/10mg

105-58-8
457 suppliers
$15.00/25g

101-97-3
481 suppliers
$14.00/25mL

Yield:101-97-3 100%

Reaction Conditions:

with Novozym 435;acylase I from Aspergillus melleus;amano lipase AK from pseudomonas fluorescens;lipase from wheat germ;papaine in toluene at 40; for 48 h;Mechanism;Enzymatic reaction;

Steps:

4.3. Experimental setup

General procedure: To the solution of acid (1 mmol) in toluene (1 ml), the corresponding dialkyl carbonate (2 mmol) and enzymes (per 4 mg of each enzyme) were added in 5 ml vial. The reaction mixture was stirring for 24 or 48 h at 40 °C in vortex mixture (Heidolph Promax 1020) equipped with incubator (Heidolph Inkubator 1000). After cooling, the mixture was washed with NaHCO₃ (3×) and brine (1×). Organic solvent was removed under vacuum to obtain the product 2a-2r.

References:

Zysk, Malgorzata;Zadlo, Anna;Brodzka, Anna;Wisniewska, Catalina;Ostaszewski, Ryszard [Journal of Molecular Catalysis B: Enzymatic,2014,vol. 102,p. 225 - 229]

64-17-5 Synthesis