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ChemicalBook CAS DataBase List Cyclobutanemethanol
4415-82-1

Cyclobutanemethanol synthesis

13synthesis methods
Cyclobutanemethanol can be synthesized from two molecules of hydrochloric acid and one molecule of cyclobutane. The synthesis pathway includes removal of a hydroxy group and addition of an alkynyl group via hydrogen bonding interactions with chloride ions.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 100 percent / diethyl ether / 0.5 h / 0 °C
2: lithium aluminum hydride / diethyl ether / 0.25 h / 25 °C

References:

Griffin;Arris;Bleasdale;Boyle;Calvert;Curtin;Dalby;Kanugula;Lembicz;Newell;Pegg;Golding [Journal of Medicinal Chemistry,2000,vol. 43,# 22,p. 4071 - 4083]

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