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ChemicalBook CAS DataBase List Aniracetam
72432-10-1

Aniracetam synthesis

9synthesis methods
Aniracetam is prepared by condensing 2-pyrrolidone with 4-methoxybenzoyl chloride. The drug was first made in the 1970s by Hoffmann-La Roche. This piracetam-related cognition enhancer reduces glutamate receptor desensitization.
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Yield:72432-10-1 91%

Reaction Conditions:

with silica gel in toluene;Reflux;Concentration;Reagent/catalyst;

Steps:

3 Example 3

Into a 250 mL four-necked flask, 150 mL of toluene, p-methoxybenzoic acid (34 g, 0.2 mol), α-pyrrolidone (17 g, 0.2 mol), silica (6 g, 10 mmol) were refluxed, and methanol was distilled off. . Methanol was evaporated and cooled to 15°C to precipitate a solid. Filter to obtain a solid cake. Dissolve with 95% ethanol, decolorize the activated carbon, filter it while hot, crystallization after cold, filter and filter cake to obtain dried aniracetam finished product 39.5g. (Yield is 91%)

References:

CN107840816,2018,A Location in patent:Paragraph 0036-0049

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