Nefiracetam synthesis
- Product Name:Nefiracetam
- CAS Number:77191-36-7
- Molecular formula:C14H18N2O2
- Molecular Weight:246.3
50-00-0
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$10.00/25g
2769-71-3
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$45.00/100mg
56-12-2
864 suppliers
$5.00/100mg
77191-36-7
277 suppliers
$15.00/50mg
Yield:77191-36-7 39%
Reaction Conditions:
in 2,2,2-trifluoroethanol at 40; for 24 h;Inert atmosphere;Ugi Condensation;
Steps:
General Procedure A
General procedure: To a solution of γ-aminobutyric acid (1.0 mmol, 1 equiv) in 2,2,2-trifluoroethanol (10 mL) were added the aldehyde (1.0 mmol, 1 equiv) and the isocyanide (1.0 mmol, 1 equiv). Unless otherwise indicated, the mixture was stirred and heated at 40 °C for 24 h. The solution was then concentrated in vacuo and the product was isolated by column chromatography on silica gel
References:
Cioc, R?zvan C.;Schaepkens van Riempst, Lola;Schuckman, Peter;Ruijter, Eelco;Orru, Romano V. A. [Synthesis,2017,vol. 49,# 7,art. no. SS-2016-T0732-OP,p. 1664 - 1674]
616-45-5
385 suppliers
$14.00/25g
1131-01-7
373 suppliers
$7.00/5g
77191-36-7
277 suppliers
$15.00/50mg