alpha-Methylcinnamic acid synthesis
- Product Name:alpha-Methylcinnamic acid
- CAS Number:1199-77-5
- Molecular formula:C10H10O2
- Molecular Weight:162.19
Yield:1199-77-5 62%
Reaction Conditions:
with potassium carbonate at 80;Micellar solution;Heck Reaction;
Steps:
A typical Heck reaction was performed in a double walledglass reactor with reflux condenser at ambient pressure. 153 μL (1.34 mmol) alkene (e.g. styrene) and 158 L (1.50 mmol) arylhalide (e.g. iodobenzene) were dissolved in 46 mL organic sol-vent or aqueous microemulsion in the presence of 0.276 g(2.00 mmol) K2CO3as base and stirred at desired reactiontemperature.1.2-1.4 g of the immobilized catalyst containing15 mg (0.067 mmol) Pd(OAc)2on silica was added to the reactionmixture and the reaction was started. For the Heck reaction withhomogeneous catalyst only 15 mg (0.067 mmol) of palladium (II)acetate was added. The reaction progress was monitored by mea-suring the reactant concentrations at different reaction times byhigh performance liquid chromatography (HPLC).
References:
Volovych;Kasaka;Schwarze;Nairoukh;Blum;Fanun;Avnir;Schom?cker [Journal of Molecular Catalysis A: Chemical,2014,vol. 393,p. 210 - 221]
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