Acetamide, 2,2,2-trifluoro-N-(trimethylsilyl)- synthesis
- Product Name:Acetamide, 2,2,2-trifluoro-N-(trimethylsilyl)-
- CAS Number:55982-15-5
- Molecular formula:C5H10F3NOSi
- Molecular Weight:185.22
Yield:55982-15-5 95%
Reaction Conditions:
at 50; for 6 h;
Steps:
1 N-trimethylsilyl trifluoroacetamide (2)
Trifluoroacetic anhydride (CF3CO)2O (8.7 g, 41 mmol)was addeddropwise to cooled (~6) hexamethyldisilazane (Me3Si)2NH(6.69 g, 41 mmol) with stirring. After the addition was complete,the final reaction mixture was slowly warmed to ~50 and stirredfor 6 h. The crude product was distilled under atmospheric pressure to give 2 (7.2 ge95%) as a colorless liquid. Bp. 142e144. 1H NMR(CDCl3, d, ppm): 0.32 (9H, s, CH3), 5.7 (1H, br. s., NH). 13C NMR(CDCl3, d, ppm): 1.16 (Me), 116 (CF3, J 320.2 Hz), 161.6 (C]O).
References:
Sterkhova, Irina V.;Nikonov, Alexey Yu;Lazarev, Igor M.;Smirnov, Vladimir I.;Lazareva, Natalya F. [Journal of Molecular Structure,2015,vol. 1098,p. 408 - 415]
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