METHYL 4-AZA-5ALPHA-ANDROSTA-1-EN-3-ONE-17BETA-CARBOXYLATE synthesis
- Product Name:METHYL 4-AZA-5ALPHA-ANDROSTA-1-EN-3-ONE-17BETA-CARBOXYLATE
- CAS Number:103335-41-7
- Molecular formula:C20H29NO3
- Molecular Weight:331.45
67-56-1
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Yield:103335-41-7 89.35%
Reaction Conditions:
with hydrogenchloride in water at 20; for 14 h;
Steps:
1 Example 1:
In a 250 mL three-necked flask, add 120 ml of methanol and 15 g of 4-Aza-5-androst-1-en-3-one-17β-carboxylic acid. Stir dry HCl gas at room temperature. After 14 hours of reaction, the reaction was completed by TLC. Evaporate the solvent under reduced pressure. Add 150 mL of dichloromethane to dissolve the product, wash it with 10% sodium hydroxide solution 30 mL×3, wash with water 30 mL×3, dry with anhydrous sodium sulfate. Concentrated under reduced pressure 4-aza-5-androst-1-en-3-one-17β-carboxylic acid methyl ester 13.9 g, The yield was 89.35%.
References:
Beijing Wanquan De Zhong Pharmaceutical Biological Co., Ltd.;Ran Zhaojin;Yan Qiqiang;Ma Sufeng;Wang Jinmin CN103539830, 2018, B Location in patent:Paragraph 0010-0011
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103335-41-7
85 suppliers
$49.00/1g