ChemicalBook CAS DataBase List 5-METHYLISOPHTHALALDEHYDE

5-METHYLISOPHTHALALDEHYDE synthesis

5synthesis methods

Product Name:5-METHYLISOPHTHALALDEHYDE
CAS Number:1805-67-0
Molecular formula:C9H8O2
Molecular Weight:148.16

27711-63-3
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1805-67-0
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Yield:1805-67-0 89%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethane at 0 - 20; for 12 h;

Steps:

5-Methylisophthalaldehyde 3

General procedure: (5-Methyl-1,3-phenylene)dimethanol 2 (1.00 g, 6.62 mmol) and PCC (3.20 g, 15.2 mmol) were dissolvedin CH2Cl2 at 0 °C. The reaction mixture was stirred for 12 h at room temperature, and insoluble materialswere removed with celite filtration. The filtrate was evaporated, and the residue was purified by columnchromatography (CH2Cl2 to AcOEt/hexane 1/2) to yield 5-methylisophthalaldehyde 3 (873 mg, 89%) as awhite-colored amorphous mass. Analytical data were identical to those reported in the literature.

References:

Hashimoto, Makoto;Murai, Yuta;Tachrim, Zetryana Puteri;Yoshida, Takuma [Heterocycles,2021,vol. 104,# 1,p. 167 - 177]

108-67-8 Synthesis