TRIMETHYL 1,3,5-BENZENETRICARBOXYLATE synthesis
- Product Name:TRIMETHYL 1,3,5-BENZENETRICARBOXYLATE
- CAS Number:2672-58-4
- Molecular formula:C12H12O6
- Molecular Weight:252.22
Yield:2672-58-4 100%
Reaction Conditions:
with sulfuric acid at 72;
Steps:
1
Benzene-1,3,5-tricarboxylic acid (50 g, 238 mmol) was dissolved in MeOH, and then conc. sulfuric acid (12.68 mL, 238 mmol) was slowly added. The solution became clear after 30 minutes of reflux and was left stirring at 72° C. for overnight. Solvent was removed under reduced pressure, the residue was dissolved in chloroform (2×800 mL) and washed with NaHCO3, then the organic solvent was removed in vacuo. (60 g, 100% yield).
References:
AMGEN INC.;MURRAY, Justin K.;HOLDER, Jerry Ryan;WANSKA, Malgorzata;TEGLEY, Christopher M.;FALSEY, James R.;DOHERTY, Elizabeth M.;MIRANDA, Leslie P.;BISWAS, Kaustav;WU, Bin;SHAM, Kelvin;LONG, Jason C. US2016/24159, 2016, A1 Location in patent:Paragraph 1042
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