5-Bromo-2,4-dichloropyrimidine synthesis
- Product Name:5-Bromo-2,4-dichloropyrimidine
- CAS Number:36082-50-5
- Molecular formula:C4HBrCl2N2
- Molecular Weight:227.87
51-20-7
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36082-50-5
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Yield:36082-50-5 99.5%
Reaction Conditions:
with phosphorus pentachloride in 1,1,2-trichloroethane;Reflux;Reagent/catalyst;Solvent;
Steps:
4 Example 4
5-bromouracil (6.0 g, 31.4 mmol) was mixed with PCl5 (16.4 g, 87.9 mmol) in a reaction flask.Add 1,1,2-trichloroethane (50 mL),The reaction mixture was heated to reflux.During the reaction, the mixture changed from a suspended state to a pale yellow clear solution.At this point TLC showed that the starting material was completely reacted.Drop to room temperature.Slowly pour the reaction mixture into stirred ice water.Stir for 1h,Add DCM (3 x 50 mL) for extraction.The organic layer was dried over anhydrous MgSO4.Evaporate the solvent,A pale yellow transparent liquid was obtained.Further purified on a silica gel column.Obtaining a colorless transparent liquid,That is, Compound 2 (yield 99.5%, purity 97%).
References:
CN108117523,2018,A Location in patent:Paragraph 0039; 0041; 0043; 0044; 0045
51-20-7
455 suppliers
$10.00/1g
36082-50-5
493 suppliers
$5.00/1g
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36082-50-5
493 suppliers
$5.00/1g