5-Bromouracil synthesis

3synthesis methods

Product Name:5-Bromouracil
CAS Number:51-20-7
Molecular formula:C4H3BrN2O2
Molecular Weight:190.98

66-22-8 Synthesis

66-22-8
799 suppliers
$5.00/10g

51-20-7
453 suppliers
$10.00/1g

Yield:51-20-7 99.9%

Reaction Conditions:

with 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione;acetic anhydride;acetic acid at 50; for 1.5 h;Temperature;Reagent/catalyst;

Steps:

1 Example 1
Uracil (100g, 892.1mmol),Solvent (glacial acetic acid (1L),Acetic anhydride (100 mL)) was mixed in a reaction flask (white suspension),Stirring reaction at 50 ° C, adding 1,3-dibromo-5,5-dimethylhydantoin(DBDMH, 153 g, 535.3 mmol), the reaction was stirred.After 1.5h,The white suspension turns into a bean curd,At this point, the TLC dot plate (sampling a little,Add THF to dilute, DCM/MeOH, 4:1),The reaction is shown to be complete.After treatment: the reaction mixture was diluted with EA,Filtering,It is dry and dry, giving a white solid.5-bromouracil(168.8 g, yield 99.9%, purity 99.3%).

References:

Shanghai Pharmaceutical Industry Institute;China Pharmaceutical Industry Zongyuan;Ma Qingtong;Shan Xiaoyan;Chen Xudong;Chen Yu CN108117524, 2018, A Location in patent:Paragraph 0025; 0026; 0030; 0032; 0034; 0036; 0042; 0044

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