ChemicalBook CAS DataBase List 4-(4-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(4-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis

8synthesis methods

Product Name:4-(4-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS Number:352437-09-3
Molecular formula:C15H21BrN2O2
Molecular Weight:341.24

66698-28-0 Synthesis

66698-28-0
144 suppliers
$10.00/250mg

24424-99-5 Synthesis

24424-99-5
840 suppliers
$13.50/25G

4-(4-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

352437-09-3
141 suppliers
$8.00/250mg

Yield:352437-09-3 90%

Reaction Conditions:

with triethylamine in dichloromethane at 0; for 3 h;Inert atmosphere;

Steps:

1.1 Step 1) 4-(4-bromophenyl)piperazine-1-carboxylic acid tert-butyl ester
Under nitrogen protection, 1-(4-Bromophenyl)piperazine (2.41 g, 10.0 mmol) was dissolved in dichloromethane (25 mL) At 0 ° C,, triethylamine (2.1 mL, 15.0 mmol) and (Boc) 2 O (2.40 g, 11.0 mmol) were added in that order, and the mixture was added to the reaction temperature for 3 h, and the reaction was completed, and the solvent was evaporated.The residue was purified on a silica gel column ( petroleum ether / ethyl acetate (v / v) = 2 / 1)concentrate,Dry to give the title compound as a white solid(3.07g, 90.0%).

References:

Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Zhang Yingjun;Jin Chuanfei CN104725363, 2019, B Location in patent:Paragraph 0346; 0348; 0349

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589-87-7 Synthesis