ChemicalBook CAS DataBase List 4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis

9synthesis methods

Product Name:4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS Number:494773-35-2
Molecular formula:C15H21BrN2O2
Molecular Weight:341.24

1011-13-8
133 suppliers
$45.00/25mg

24424-99-5 Synthesis

24424-99-5
835 suppliers
$13.50/25G

4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

494773-35-2
70 suppliers
$16.00/100 mg

Yield: 91%

Reaction Conditions:

in ethanol at 30;

Steps:

2
The above solid was dissolved in 100 ml of absolute ethanol, and Boc2O13.1g (0.06mo1) was added, and the mixture was stirred at 30 ° C until the reaction was completed, concentrated to dryness under reduced pressure, and crystallized from n-hexane-ethyl acetate to obtain4- (2-Bromophenyl) piperazine-1-carboxylic acid tert-butyl ester18.6g, yield 91%.

References:

Jiangsu Haosen Pharmaceutical Group Co., Ltd.;Cao Jin;You Junhui;Du Zuyin;Zhao Junjun;Qi Gaofei CN104829558, 2020, B Location in patent:Paragraph 0066; 0067; 0070; 0071

57260-71-6 Synthesis