(2S)-2-(2-Oxopyrrolidin-1-yl)butanoic acid synthesis
- Product Name:(2S)-2-(2-Oxopyrrolidin-1-yl)butanoic acid
- CAS Number:102849-49-0
- Molecular formula:C8H13NO3
- Molecular Weight:171.19
102916-46-1
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102849-49-0
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Yield: 90%
Reaction Conditions:
with hydrogenchloride in water
Steps:
3
EXAMPLE 3; Preparation of (ιS)-alpha-Ethyl-2-oxo-l-pyrrolidineacetic acid (i?)-alpha- methylbenzylamine salt; A solution of (i?)-alpha-methylbenzylamine (106 g) and triethylamine (89 g) in toluene (100 ml) was added to a suspension of (i?iS)-alpha-ethyl-2-oxo-l- pyrrolidineacetic acid (300 g, 1.75 mol) in toluene (IL). The mixture was heated until complete dissolution, cooled to room temperature and stirred for 3 hours. The solids were filtered and rinsed with toluene (300 ml) to give 250 g of (iS)-alpha-ethyl-2-oxo-l- pyrrolidineacetic acid (i?)-alpha-methylbenzylamine salt. The solids were crystallized from toluene and 205 g (yield 41%) of ()S)-alpha-ethyl-2-oxo-l -pyrrolidineacetic acid (i?)-alpha-methylbenzylamine salt was obtained. The isolated solid was treated with hydrochloric acid solution and the enantiomerically pure (iS)-alpha-ethyl-2-oxo-l~ pyrrolidineacetic acid could be isolated in 90% yield.
References:
APOTEX PHARMACHEM INC. WO2006/53441, 2006, A1 Location in patent:Page/Page column 13
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909566-58-1
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102849-49-0
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1000210-73-0
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102849-49-0
158 suppliers
$95.00/100mg
909566-58-1
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$290.00/10 mg
103833-72-3
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102849-49-0
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616-45-5
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$14.00/5g
2681-94-9
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$200.00/100 mg
102849-49-0
158 suppliers
$95.00/100mg