ChemicalBook CAS DataBase List 2-Bromoquinoline

2-Bromoquinoline synthesis

10synthesis methods

Product Name:2-Bromoquinoline
CAS Number:2005-43-8
Molecular formula:C9H6BrN
Molecular Weight:208.05

93-10-7 Synthesis

93-10-7
317 suppliers
$6.00/5g

2005-43-8
209 suppliers
$6.00/250mg

Yield:2005-43-8 75%

Reaction Conditions:

with tert-butylhypochlorite;sodium carbonate;sodium bromide at 60; for 20 h;Schlenk technique;

Steps:

10 Example 10: Synthesis of 2-bromoquinoline (2j)
Weighing quinoline-2-carboxylic acid (51.9 mg, 0.3 mmol),Sodium carbonate (64.0 mg, 0.6 mmol), NaBr (17.6 mg, 0.3 mmol), tert-butyl hypochlorite (32 μL, 0.3 mmol) into a 25 mL of Schlenk reaction bottle, Then CH2Br2 (2 mL) was added and placed in a 60 °C oil bath for 20 h. After completion of the reaction, the solvent was removed under reduced pressure and eluted with petroleum ether / ethyl acetate.The solvent was separated on a silica gel column, he yield of 2-bromoquinoline was 75%.

References:

Dalian University of Technology;Feng Xiujuan;Zhang Xitao;Zhang Haixia;Bao Ming CN108586334, 2018, A Location in patent:Paragraph 0072-00374

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606-43-9 Synthesis