8-Bromoquinoline synthesis
- Product Name:8-Bromoquinoline
- CAS Number:16567-18-3
- Molecular formula:C9H6BrN
- Molecular Weight:208.05
86-58-8
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16567-18-3
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Yield:16567-18-3 90%
Reaction Conditions:
with tetrabutylammomium bromide;copper(ll) bromide in water at 100;Sealed tube;
Steps:
1. Preparation of aryl bromides
General procedure: To a stirred solution of arylboronic acids 1 (1 mmol), CuBr2 (335 mg, 1.5 mmol), TBAB (33 mg, 0.1 mmol) water (5mL) in a sealed tube for 5-12 h at 100 °C. After completion of the reaction as indicated by TLC, the mixture was extracted with EtOAc (2×5 mL). The organic layer was dried by anhydrous Na2SO4, concentrated in vacuo, and the residue was isolated by simply column chromatography (PE/EA 40:1-20:1) to afford products, respectively.
References:
Tang, Yan-Ling;Xia, Xian-Song;Gao, Jin-Chun;Li, Min-Xin;Mao, Ze-Wei [Tetrahedron Letters,2021,vol. 64,art. no. 152738] Location in patent:supporting information
937640-02-3
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16567-18-3
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578-66-5
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16567-18-3
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3054-95-3
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615-36-1
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16567-18-3
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$6.00/1g