2,2-DIFLUOROETHYLAMINE synthesis
- Product Name:2,2-DIFLUOROETHYLAMINE
- CAS Number:430-67-1
- Molecular formula:C2H5F2N
- Molecular Weight:81.06
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430-67-1
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Yield:430-67-1 82%
Reaction Conditions:
with ammonia;potassium iodide in dimethyl sulfoxide at 100; for 1 h;Product distribution / selectivity;Autoclave;
Steps:
3
Example 3; An autoclave is initially charged with 14,5 g (0.1 mol) of 2,2-difluoro-l-bromoethane, 0.5 g of potassium iodide and 50 g of DMSO having a water content of 250 ppm, i.e. 0.025% by volume, and 6.8 g of anhydrous ammonia are added. The molar ratio of 2,2-difluoro-1-bromoethane to ammonia is 1:4. The reaction mixture is heated to 100° C. and stirred at this temperature for 1 hour. The reaction mixture is cooled to 50° C. and the excess ammonia is distilled off. The difluoroethylamine is subsequently distilled out of the reaction mixture at 1-10 mbar. The distillate, which still contains small amounts of solvent, is then redistilled at standard pressure. This gives 82% yield.
References:
Bayer CropScience AG US2011/60167, 2011, A1 Location in patent:Page/Page column 3
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430-67-1
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