(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID synthesis

6synthesis methods

Product Name:(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
CAS Number:147266-92-0
Molecular formula:C10H17NO5
Molecular Weight:231.25

24424-99-5 Synthesis

24424-99-5
833 suppliers
$13.50/25G

51-35-4 Synthesis

51-35-4
849 suppliers
$6.00/5g

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

147266-92-0
173 suppliers
$60.00/100 mg

Yield:147266-92-0 90%

Reaction Conditions:

with sodium hydroxide in 1,4-dioxane at 0 - 20;

Steps:

1.A
Preparation 1: Methyl (25,45)-l-Boc-4-aminopyrrolidin-2-carboxyIate [285] Step A: ⁽4/?⁾-l-Boc-4-hydroxy-L-proline [286] (4/?)-hydroxy-L-proline (5.08 g, 38.77 mmol) was dissolved in IN NaOH (40 ml) and 1,4-dioxane (40 ml), and to the resulting solution, di-t-butyl dicarbonate (9.3g, 42.6 mmol) was added dropwise at 0⁰C. The reaction mixture was stirred at room tem_? perature for 8 hours, concentrated in vacuo, acidified with IN HCl, and extracted with EtOAc. The organic extracts were washed with brine, dried over MgSO₄, filtered, and concentrated in vacuo to give the title compound (8.84g_, 99 %₎.[287] MS[M+H] = 232 (M+l) [288] [289]

References:

LG LIFE SCIENCES LTD. WO2010/56022, 2010, A2 Location in patent:Page/Page column 21

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24424-99-5 Synthesis

24424-99-5
833 suppliers
$13.50/25G

3398-22-9 Synthesis