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ChemicalBook CAS DataBase List (4R)-4-Hydroxy-1-Boc-D-proline ethyl ester
77450-00-1

(4R)-4-Hydroxy-1-Boc-D-proline ethyl ester synthesis

13synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
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2-(R)-CARBOETHOXY-4-(R)-HYDROXYPYRROLIDINE

132666-67-2
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Yield:77450-00-1 100%

Reaction Conditions:

with sodium hydrogencarbonate in 1,4-dioxane;water at 0 - 20;

References:

Watanabe, Akiko;Kiyota, Naotoshi;Yamasaki, Tetsuo;Tanda, Kazuhiro;Miyagoe, Tatsunori;Sakamoto, Masanori;Otsuka, Masami [Journal of Heterocyclic Chemistry,2011,vol. 48,# 5,p. 1132 - 1139] Location in patent:experimental part