ChemicalBook CAS DataBase List N-Boc-cis-4-Hydroxy-L-proline

N-Boc-cis-4-Hydroxy-L-proline synthesis

10synthesis methods

Product Name:N-Boc-cis-4-Hydroxy-L-proline
CAS Number:87691-27-8
Molecular formula:C10H17NO5
Molecular Weight:231.25

84348-37-8 Synthesis

84348-37-8
283 suppliers
$5.00/250mg

87691-27-8
226 suppliers
$6.00/250mg

Yield:87691-27-8 99.1%

Reaction Conditions:

with sodium tetrahydroborate in methanol at 0 - 5;

Steps:

3.b Preparation of product cis-F-1

The reducing agent (4.0 to 5.0 e.q.) was added to the solvent,Cold to a certain temperature,Add the substrate in batches to exotherm,HPLC monitoring reaction,Reaction is completed,The reaction solution was added to water,Cooling to 0 ~ 5C,With dilute hydrochloric acid pH 2 ~ 3, EA extraction(5X * 3). The combined organic phases were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the crude product. The crude productThe product was crystallized from a mixed solvent of ethyl acetate and alkane.

References:

CN106543062,2017,A Location in patent:Paragraph 0021; 0024; 0027

24424-99-5 Synthesis