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ChemicalBook >> CAS DataBase List >> XL019

XL019

XL019 price.
  • $48 - $3980
  • Product name: XL019
  • CAS: 945755-56-6
  • MF: C25H28N6O2
  • MW: 444.53
  • EINECS:-0
  • MDL Number:MFCD24386874
  • Synonyms:2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide XL019;XL019 2-Pyrrolidinecarboxamide, N-[4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-, (2S)-;Pyrrolidine-2-carboxylic acid {4-[2-(4-morpholin-4-yl-phenylamino)-pyrimidin-4-yl]-phenyl}-amide;XL019, >=98%;XL019;XL019/XL-019;(2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide;(S)-N-(4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)PHENYL)PYRROLIDINE-2-CARBOXAMIDE
36 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1MG
  • 2mg
  • 5mg
  • 2x5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2807AH
  • Product description(2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide
  • Packaging5mg
  • Price$193
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging2mg
  • Price$48
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging5mg
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging25mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging50mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging100mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging250mg
  • Price$351
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA403201
  • Product descriptionXL019 98+%
  • Packaging1g
  • Price$876
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024547
  • Product descriptionXL-019 95.00%
  • Packaging1MG
  • Price$340.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024547
  • Product descriptionXL-019 95.00%
  • Packaging5MG
  • Price$496.95
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3937
  • Product descriptionXL019
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3937
  • Product descriptionXL019
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2231
  • Product descriptionXL019 99%
  • Packaging2x5mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2231
  • Product descriptionXL019 99%
  • Packaging25mg
  • Price$385
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146222
  • Product descriptionXL019 >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2807AH (2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide 5mg $193 2021-12-16 Buy
Ambeed A403201 XL019 98+% 2mg $48 2021-12-16 Buy
Ambeed A403201 XL019 98+% 5mg $62 2021-12-16 Buy
Ambeed A403201 XL019 98+% 10mg $80 2021-12-16 Buy
Ambeed A403201 XL019 98+% 25mg $104 2021-12-16 Buy
Ambeed A403201 XL019 98+% 50mg $135 2021-12-16 Buy
Ambeed A403201 XL019 98+% 100mg $176 2021-12-16 Buy
Ambeed A403201 XL019 98+% 250mg $351 2021-12-16 Buy
Ambeed A403201 XL019 98+% 1g $876 2021-12-16 Buy
American Custom Chemicals Corporation API0024547 XL-019 95.00% 1MG $340.2 2021-12-16 Buy
American Custom Chemicals Corporation API0024547 XL-019 95.00% 5MG $496.95 2021-12-16 Buy
ApexBio Technology A3937 XL019 5mg $90 2021-12-16 Buy
ApexBio Technology A3937 XL019 50mg $450 2021-12-16 Buy
Axon Medchem Axon2231 XL019 99% 2x5mg $176 2021-12-16 Buy
Axon Medchem Axon2231 XL019 99% 25mg $385 2021-12-16 Buy
Biorbyt Ltd orb146222 XL019 >98% 100mg $838.1 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥11.125 mg/mL in DMSO
form :solid
color :Green to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P314 Get medical advice/attention if you feel unwell.
P501 Dispose of contents/container to..…

Description

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. XL019 is a potent, bioavailable JAK inhibitor with preference for JAK2 (IC50 = 2 nM) over JAK1 and JAK3 (IC50s = 130 and 250 nM, respectively). It is effective against JAK2V617F as well as JAK2 and inhibits phosphorylation of STAT5 in vivo.

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