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ChemicalBook >> CAS DataBase List >> XL888

XL888

XL888 price.
  • $49 - $4321.4
  • Product name: XL888
  • CAS: 1149705-71-4
  • MF: C29H37N5O3
  • MW: 503.64
  • EINECS:
  • MDL Number:
  • Synonyms:1,4-Benzenedicarboxamide, N1-[(3-endo)-8-[5-(cyclopropylcarbonyl)-2-pyridinyl]-8-azabicyclo[3.2.1]oct-3-yl]-2-methyl-5-[[(1R)-1-methylpropyl]amino]-;XL 888, >=98%;XL888;5-((R)-sec-butylaMino)-N1-((1R,3r,5S)-8-(5-(cyclopropanecarbonyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-2-MethylterephthalaMide;N1-[(3-endo)-8-[5-(Cyclopropylcarbonyl)-2-pyridinyl]-8-azabicyclo[3.2.1]oct-3-yl]-2-methyl-5-[[(1R)-1-methylpropyl]amino]-1,4-benzenedicarboxamide;CS-831;CS-2629;XL888; XL-888; XL 888
22 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2810AH
  • Product description2-[[(2R)-Butan-2-yl]amino]-4-N-[(1S,5R)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide
  • Packaging10mg
  • Price$367
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2810AH
  • Product description2-[[(2R)-Butan-2-yl]amino]-4-N-[(1S,5R)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide
  • Packaging5mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2810AH
  • Product description2-[[(2R)-Butan-2-yl]amino]-4-N-[(1S,5R)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide
  • Packaging1mg
  • Price$101
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4388
  • Product descriptionXL-888
  • Packaging5mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180877
  • Product descriptionXL888 >98%
  • Packaging100mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180877
  • Product descriptionXL888 >98%
  • Packaging250mg
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180877
  • Product descriptionXL888 >98%
  • Packaging1g
  • Price$4321.4
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16309
  • Product descriptionXL888 ≥98%
  • Packaging1mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16309
  • Product descriptionXL888 ≥98%
  • Packaging5mg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16309
  • Product descriptionXL888 ≥98%
  • Packaging10mg
  • Price$333
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16309
  • Product descriptionXL888 ≥98%
  • Packaging25mg
  • Price$593
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003194
  • Product descriptionXL888 99.62%
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003194
  • Product descriptionXL888 99.62%
  • Packaging5mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003194
  • Product descriptionXL888 99.62%
  • Packaging10mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003194
  • Product descriptionXL888 99.62%
  • Packaging25mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003194
  • Product descriptionXL888 99.62%
  • Packaging50mg
  • Price$820
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2810AH 2-[[(2R)-Butan-2-yl]amino]-4-N-[(1S,5R)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide 10mg $367 2021-12-16 Buy
AK Scientific 2810AH 2-[[(2R)-Butan-2-yl]amino]-4-N-[(1S,5R)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide 5mg $250 2021-12-16 Buy
AK Scientific 2810AH 2-[[(2R)-Butan-2-yl]amino]-4-N-[(1S,5R)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide 1mg $101 2021-12-16 Buy
ApexBio Technology A4388 XL-888 5mg $160 2021-12-16 Buy
Biorbyt Ltd orb180877 XL888 >98% 100mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb180877 XL888 >98% 250mg $2245.7 2021-12-16 Buy
Biorbyt Ltd orb180877 XL888 >98% 1g $4321.4 2021-12-16 Buy
Cayman Chemical 16309 XL888 ≥98% 1mg $49 2024-03-01 Buy
Cayman Chemical 16309 XL888 ≥98% 5mg $216 2024-03-01 Buy
Cayman Chemical 16309 XL888 ≥98% 10mg $333 2024-03-01 Buy
Cayman Chemical 16309 XL888 ≥98% 25mg $593 2024-03-01 Buy
ChemScene CS-0003194 XL888 99.62% 1mg $50 2021-12-16 Buy
ChemScene CS-0003194 XL888 99.62% 5mg $150 2021-12-16 Buy
ChemScene CS-0003194 XL888 99.62% 10mg $240 2021-12-16 Buy
ChemScene CS-0003194 XL888 99.62% 25mg $450 2021-12-16 Buy
ChemScene CS-0003194 XL888 99.62% 50mg $820 2021-12-16 Buy

Properties

Boiling point :695.1±55.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥18.2 mg/mL in DMSO
form :solid
pka :14.33±0.20(Predicted)
color :Off-white to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. XL888 is an ATP-competitive inhibitor of Hsp90. Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis. XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice.

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