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ChemicalBook >> CAS DataBase List >> Paclitaxel

Paclitaxel

Paclitaxel price.
  • $30 - $4200
  • Product name: Paclitaxel
  • CAS: 33069-62-4
  • MF: C47H51NO14
  • MW: 853.92
  • EINECS:608-826-9
  • MDL Number:MFCD00869953
  • Synonyms:N-BENZYL-BETA-PHENYLISOSERINE ESTER;PACLITAXEL, TAXUS BREVIFOLIA;PACLITAXEL, TAXUS SPECIES;PACLITAXOL;PACLITAXEL;TAXOL(TM);taxol a;TAXOL EQUIVALENT
87 prices
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  • y0000700
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0045-M025
  • Product descriptionPaclitaxel ≥99%(HPLC)
  • Packaging25mg
  • Price$92
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ98747
  • Product descriptionPaclitaxel
  • Packaging250mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberA648
  • Product descriptionPaclitaxel
  • Packaging500mg
  • Price$323
  • Updated2021-12-16
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  • ManufacturerAlfa Aesar
  • Product numberJ62734
  • Product descriptionPaclitaxel, 99.5+%
  • Packaging100mg
  • Price$140
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ62734
  • Product descriptionPaclitaxel, 99.5+%
  • Packaging500mg
  • Price$387
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ62734
  • Product descriptionPaclitaxel, 99.5+%
  • Packaging1g
  • Price$727
  • Updated2024-03-01
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4393
  • Product descriptionPaclitaxel(Taxol)
  • Packaging50mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISC1043
  • Product descriptionPaclitaxel-[2H5]
  • Packaging1mg
  • Price$777
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBISC1043
  • Product descriptionPaclitaxel-[2H5]
  • Packaging5mg
  • Price$2802
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN97759
  • Product descriptionPaclitaxel
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
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  • ManufacturerAstaTech
  • Product numberN88686
  • Product descriptionPaclitaxel 97%
  • Packaging1/ G
  • Price$166
  • Updated2021-12-16
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  • ManufacturerAstaTech
  • Product numberN88686
  • Product descriptionPaclitaxel 97%
  • Packaging5/ G
  • Price$499
  • Updated2021-12-16
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  • ManufacturerAstaTech
  • Product numberN88686
  • Product descriptionPaclitaxel 97%
  • Packaging10/ G
  • Price$749
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1364
  • Product descriptionPaclitaxel
  • Packaging250mg
  • Price$59
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1364
  • Product descriptionPaclitaxel
  • Packaging1g
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1364
  • Product descriptionPaclitaxel
  • Packaging5g
  • Price$395
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0045-M025 Paclitaxel ≥99%(HPLC) 25mg $92 2021-12-16 Buy
AK Scientific J98747 Paclitaxel 250mg $116 2021-12-16 Buy
AK Scientific A648 Paclitaxel 500mg $323 2021-12-16 Buy
Alfa Aesar J62734 Paclitaxel, 99.5+% 100mg $140 2024-03-01 Buy
Alfa Aesar J62734 Paclitaxel, 99.5+% 500mg $387 2024-03-01 Buy
Alfa Aesar J62734 Paclitaxel, 99.5+% 1g $727 2024-03-01 Buy
ApexBio Technology A4393 Paclitaxel(Taxol) 50mg $50 2021-12-16 Buy
Apolloscientific BISC1043 Paclitaxel-[2H5] 1mg $777 2021-12-16 Buy
Apolloscientific BISC1043 Paclitaxel-[2H5] 5mg $2802 2021-12-16 Buy
Arctom CFN97759 Paclitaxel 20mg $30 2021-12-16 Buy
AstaTech N88686 Paclitaxel 97% 1/ G $166 2021-12-16 Buy
AstaTech N88686 Paclitaxel 97% 5/ G $499 2021-12-16 Buy
AstaTech N88686 Paclitaxel 97% 10/ G $749 2021-12-16 Buy
AvaChem 1364 Paclitaxel 250mg $59 2021-12-16 Buy
AvaChem 1364 Paclitaxel 1g $105 2021-12-16 Buy
AvaChem 1364 Paclitaxel 5g $395 2021-12-16 Buy

Properties

Melting point :213 °C (dec.)(lit.)
Boiling point :774.66°C (rough estimate)
alpha :D20 -49° (methanol)
Density :0.200
refractive index :-49 ° (C=1, MeOH)
Flash point :9℃
storage temp. :2-8°C
solubility :methanol: 50 mg/mL, clear, colorless
form :powder
pka :11.90±0.20(Predicted)
color :white
Water Solubility :0.3mg/L(37 ºC)
λmax :227nm(MeOH)(lit.)
Merck :14,6982
BRN :1420457
Stability :Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey :RCINICONZNJXQF-MZXODVADSA-N
LogP :3.950 (est)
CAS DataBase Reference :33069-62-4(CAS DataBase Reference)
EPA Substance Registry System :Paclitaxel (33069-62-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values ranging from 2.5-7.5 nM. Paclitaxel disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC50s = 6.7-18.5 nM) at both prophase and G1. It initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.

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