Sitagliptin
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- $8 - $1504.5
- Product name: Sitagliptin
- CAS: 486460-32-6
- MF: C16H15F6N5O
- MW: 407.31
- EINECS:690-730-1
- MDL Number:MFCD09838015
- Synonyms:Sitagliptin;(3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one;Sitagliptin-D4 HCL;Hsdb 7516;C53323300;Metformin / sitagliptin;Metformin hydrochloride mixture with sitagliptin phosphate;Metformin mixture with sitagliptin
29 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- ChemScene
- DC Chemicals
- Labseeker
- TRC
Package
- 5MG
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 2g
- 5g
- 10g
- 25g
- 50g
- 1kg
- ManufacturerAK Scientific
- Product numberX4663
- Product descriptionSitagliptin
- Packaging100mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ96214
- Product descriptionSitagliptin
- Packaging10g
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA127061
- Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
- Packaging100mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA127061
- Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
- Packaging250mg
- Price$13
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA127061
- Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
- Packaging1g
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA127061
- Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
- Packaging5g
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA127061
- Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
- Packaging10g
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA127061
- Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
- Packaging25g
- Price$247
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberRDL0007146
- Product descriptionSITAGLIPTIN-D4 95.00%
- Packaging5MG
- Price$497.41
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2201B
- Product descriptionSitagliptin
- Packaging100mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2201B
- Product descriptionSitagliptin
- Packaging1g
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2201B
- Product descriptionSitagliptin
- Packaging10g
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3251
- Product descriptionSitagliptin 100%
- Packaging50mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146262
- Product descriptionSitagliptin (Metformin,MK-0431) >98%
- Packaging100mg
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146262
- Product descriptionSitagliptin (Metformin,MK-0431) >98%
- Packaging250mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146262
- Product descriptionSitagliptin (Metformin,MK-0431) >98%
- Packaging1g
- Price$1504.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X4663 | Sitagliptin | 100mg | $95 | 2021-12-16 | Buy |
| AK Scientific | J96214 | Sitagliptin | 10g | $160 | 2021-12-16 | Buy |
| Ambeed | A127061 | (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% | 100mg | $8 | 2021-12-16 | Buy |
| Ambeed | A127061 | (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% | 250mg | $13 | 2021-12-16 | Buy |
| Ambeed | A127061 | (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% | 1g | $33 | 2021-12-16 | Buy |
| Ambeed | A127061 | (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% | 5g | $99 | 2021-12-16 | Buy |
| Ambeed | A127061 | (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% | 10g | $158 | 2021-12-16 | Buy |
| Ambeed | A127061 | (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% | 25g | $247 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0007146 | SITAGLIPTIN-D4 95.00% | 5MG | $497.41 | 2021-12-16 | Buy |
| AvaChem | 2201B | Sitagliptin | 100mg | $39 | 2021-12-16 | Buy |
| AvaChem | 2201B | Sitagliptin | 1g | $149 | 2021-12-16 | Buy |
| AvaChem | 2201B | Sitagliptin | 10g | $490 | 2021-12-16 | Buy |
| Axon Medchem | Axon3251 | Sitagliptin 100% | 50mg | $55 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146262 | Sitagliptin (Metformin,MK-0431) >98% | 100mg | $510 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146262 | Sitagliptin (Metformin,MK-0431) >98% | 250mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146262 | Sitagliptin (Metformin,MK-0431) >98% | 1g | $1504.5 | 2021-12-16 | Buy |
Properties
Melting point :114.1-115.7 °C
Boiling point :529.9±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 50 mg/mL (122.76 mM)
pka :7.20±0.10(Predicted)
form :Solid
color :White to off-white
InChI :InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey :MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES :C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference :486460-32-6(CAS DataBase Reference)
EPA Substance Registry System :1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)
Boiling point :529.9±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 50 mg/mL (122.76 mM)
pka :7.20±0.10(Predicted)
form :Solid
color :White to off-white
InChI :InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey :MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES :C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference :486460-32-6(CAS DataBase Reference)
EPA Substance Registry System :1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)
Safety Information
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Description
Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.More related product prices
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