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Postion:Product Catalog >API>Circulatory system drugs>Lipid regulating drugs>Sitagliptin
Sitagliptin
  • Sitagliptin

Sitagliptin NEW

Price Get Latest Price
Package 10g 100g 1000g
Min. Order: 10g
Supply Ability: 10000
Update Time: 2024-12-26

Product Details

Product Name: Sitagliptin CAS No.: 486460-32-6
Min. Order: 10g Purity: 99% HPLC
Supply Ability: 10000 Release date: 2024/12/26

Description: Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an Ic50 of 19 nM in Caco-2 cell extractsSitagliptin is believed to exert its actions in patients with type 2 diabetes melitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases qlucagon levels inthe circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for Dpp-4 and does not inhibit DPp-8 orDPp-9 activity in vitro at concentrations approximating those from therapeutic doses.

Synonym: Sitagliptin; LEZ 763; LEZ-763; LEZ763; MK0431; MK 0431; MK-0431;IUPAC/chemical Name: (R)-3-amino-1-(3-(trifluoromethyl)-5,6- dihydro-[1,2,4]triazolof4,3-alpyrazin-7(8H)-yl)-4-(2,4, 5-trifluo

rophenyl)butan-1-oneInchi 

Key:MFFMDFFZMYYVKSSECBINFHSA-NInchi code: Inchl=1S/C16H15F6N50/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1

SMILES Code: FC(C1=NN=C2CN(C(C[C@H](N)CC3=CC(F)=C(F)C=C3F)=0)CCN21)(F)

FAppearance: Solid powder

Purity:>98% (or refer to the Certificate of Analysis)

Shipping Condition: shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMso

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Company Profile Introduction

Hangzhou Runyan Pharmaceutical Technology Co., Ltd. is a high-tech enterprise specializing in the production and research and development of nucleotide and anti-virus products. The products are mainly used in pharmaceutical intermediates, veterinary drugs, food additives and other fields. After years of exploration and efforts, it has formed antiviral agents such as Oseltamivirphosphate, Remdesivir, Molnupiravir, Nirmatrelvir and other anti-virus products.And Cabozantinib Malate, Selpercatinib, Poziotinib and Isotinic Anti-Cancer pharmaceutical intermediates, polyinosinic-polycytidylic acid sodium salt, Adenosine Cyclophosphate , Uridine 5'-monophosphate disodium salt, Adenosine Triphosphate Disodium, Adenosine 5'-monophosphate, Adenosine and other nucleotides production and operation mode of nucleotide series products. The enterprise has a sound operating mechanism, with a central laboratory, a 100000 level purification workshop meeting GMP standards, several intelligent computer controlled batching workshops, full-automatic product packaging lines and professional transport institutions, production equipment and internationally leading production technology. Based on the principle of "moistening the world, beaming with joy", the company is constantly exploring the original road to achieve greater progress and development. We warmly welcome and look forward to common development and progress with customers at home and abroad!

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  • Since: 2022-10-14
  • Address: Room 530, 5F, building 10, Xintiandi business center, Gongshu District, Hangzhou City, Zhejiang Prov
INQUIRY

+86-18882027439
sales2@runyanpharma.com