REVIEW Sitagliptin is an orally available hypoglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. It is for use as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.
REFERENCES
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Sorbera, L. A.; Castaner, J. MK-0431: agent for type 2 diabetes and dipeptidyl-peptidase IV (CD26) inhibitor. Drugs of the Future. (2005) 30(4): 337-343.
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Bardsley, Joan K.; Ratner, Robert E.Sitagliptin: an oral agent for glucose control Expert Review of Endocrinology & Metabolism (2008), 3(6), 691-697.
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Dhillon, Sohita. Sitagliptin: a review of its use in the management of type 2 diabetes mellitus. Drugs. (2010) 70(4): 489-512.
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Edmondson, Scott D.; Fisher, Michael H.; Kim, Dooseop; MacCoss, Malcolm; Parmee, Emma R.; Weber, Ann E.; Xu, Jinyou Preparation of beta-amino tetrahydroimidazo[1,2-a]pyrazines and tetrahydrotrioazolo[4,3-a]pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes PCT Int. Appl. (2003), WO 2003004498 A1 20030116.
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