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ChemicalBook >> CAS DataBase List >> SD-208

SD-208

SD-208 price.
  • $9 - $1600
  • Product name: SD-208
  • CAS: 627536-09-8
  • MF: C17H10ClFN6
  • MW: 352.75
  • EINECS:
  • MDL Number:MFCD09038685
  • Synonyms:SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE;2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine;2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine;4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-;2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;SCI 208;2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
34 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1mg
  • 2MG
  • 5mg
  • 10mg
  • 10
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number4032AH
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
  • Packaging5mg
  • Price$146
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150813
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
  • Packaging1mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150813
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
  • Packaging5mg
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150813
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
  • Packaging10mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150813
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
  • Packaging50mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150813
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
  • Packaging100mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150813
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
  • Packaging250mg
  • Price$166
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150813
  • Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
  • Packaging1g
  • Price$423
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000302
  • Product descriptionSD-208 95.00%
  • Packaging2MG
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000302
  • Product descriptionSD-208 95.00%
  • Packaging10MG
  • Price$755.48
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000302
  • Product descriptionSD-208 95.00%
  • Packaging50MG
  • Price$1385.77
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3808
  • Product descriptionSD-208
  • Packaging10mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3808
  • Product descriptionSD-208
  • Packaging50mg
  • Price$768
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS99545
  • Product descriptionSCI 208
  • Packaging5mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS99545
  • Product descriptionSCI 208
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS99545
  • Product descriptionSCI 208
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4032AH 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 5mg $146 2021-12-16 Buy
Ambeed A150813 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% 1mg $9 2021-12-16 Buy
Ambeed A150813 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% 5mg $19 2021-12-16 Buy
Ambeed A150813 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% 10mg $28 2021-12-16 Buy
Ambeed A150813 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% 50mg $70 2021-12-16 Buy
Ambeed A150813 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% 100mg $105 2021-12-16 Buy
Ambeed A150813 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% 250mg $166 2021-12-16 Buy
Ambeed A150813 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% 1g $423 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000302 SD-208 95.00% 2MG $185 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000302 SD-208 95.00% 10MG $755.48 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000302 SD-208 95.00% 50MG $1385.77 2021-12-16 Buy
ApexBio Technology A3808 SD-208 10mg $182 2021-12-16 Buy
ApexBio Technology A3808 SD-208 50mg $768 2021-12-16 Buy
Biosynth Carbosynth FS99545 SCI 208 5mg $35 2021-12-16 Buy
Biosynth Carbosynth FS99545 SCI 208 10mg $100 2021-12-16 Buy
Biosynth Carbosynth FS99545 SCI 208 25mg $200 2021-12-16 Buy

Properties

Boiling point :460.4±45.0 °C(Predicted)
Density :1.487
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :4.56±0.26(Predicted)
form :powder
color :off-white to tan

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

TGF-β is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies. TGF-β signals through two receptor tyrosine kinases, TGF-βRI and TGF-βRII. SD 208 is a potent inhibitor of TGF-βRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including TGF-βRII kinase. It blocks both autocrine and paracrine TGF-β signaling in glioma cells, inhibiting TGF-β-induced migration and invasion without affecting viability or proliferation. SD 208 is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains of mice. It improves survival in mice with xenografted glioma by heightening the immune response against tumor cells and reverses bronchial hyperresponsiveness to allergens in ovalbumin-exposed mice. SD 208 also suppresses TGF-β-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of TGF-β.

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