xav-939
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- $7 - $2097.8
- Product name: xav-939
- CAS: 284028-89-3
- MF: C14H11F3N2OS
- MW: 312.31
- EINECS:687-302-1
- MDL Number:MFCD00106866
- Synonyms:2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one;XAV-939;XAV 939;xav-939;3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one;XAV 939/NVP-XAV939;XAV 939, >=98%;SteMolecule;1,5,7,8-Tetrahydro-2-[4-(trifluoroMethyl)phenyl]-4H-thiopyrano[4,3-d]pyriMidin-4-one
40 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 10mg
- 25mg
- 2x25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7558
- Product descriptionXAV 939
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA180960
- Product descriptionXAV 939 98+%
- Packaging1mg
- Price$7
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA180960
- Product descriptionXAV 939 98+%
- Packaging5mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA180960
- Product descriptionXAV 939 98+%
- Packaging10mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA180960
- Product descriptionXAV 939 98+%
- Packaging50mg
- Price$51
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA180960
- Product descriptionXAV 939 98+%
- Packaging100mg
- Price$76
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA180960
- Product descriptionXAV 939 98+%
- Packaging250mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA180960
- Product descriptionXAV 939 98+%
- Packaging1g
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1877
- Product descriptionXAV 939
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60028
- Product descriptionXAV 939
- Packaging10mg
- Price$148
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1527
- Product descriptionXAV939-NVP-XAV939 99%
- Packaging2x25mg
- Price$264
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1527
- Product descriptionXAV939-NVP-XAV939 99%
- Packaging10mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180747
- Product descriptionXAV 939 >98%
- Packaging1g
- Price$2097.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180747
- Product descriptionXAV 939 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180747
- Product descriptionXAV 939 >98%
- Packaging100mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545850
- Product descriptionXAV 939 >98%
- Packaging5mg
- Price$146.2
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7558 | XAV 939 | 10mg | $80 | 2021-12-16 | Buy |
| Ambeed | A180960 | XAV 939 98+% | 1mg | $7 | 2021-12-16 | Buy |
| Ambeed | A180960 | XAV 939 98+% | 5mg | $14 | 2021-12-16 | Buy |
| Ambeed | A180960 | XAV 939 98+% | 10mg | $20 | 2021-12-16 | Buy |
| Ambeed | A180960 | XAV 939 98+% | 50mg | $51 | 2021-12-16 | Buy |
| Ambeed | A180960 | XAV 939 98+% | 100mg | $76 | 2021-12-16 | Buy |
| Ambeed | A180960 | XAV 939 98+% | 250mg | $122 | 2021-12-16 | Buy |
| Ambeed | A180960 | XAV 939 98+% | 1g | $308 | 2021-12-16 | Buy |
| ApexBio Technology | A1877 | XAV 939 | 5mg | $50 | 2021-12-16 | Buy |
| Arctom | CFN60028 | XAV 939 | 10mg | $148 | 2021-12-16 | Buy |
| Axon Medchem | Axon1527 | XAV939-NVP-XAV939 99% | 2x25mg | $264 | 2021-12-16 | Buy |
| Axon Medchem | Axon1527 | XAV939-NVP-XAV939 99% | 10mg | $88 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180747 | XAV 939 >98% | 1g | $2097.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180747 | XAV 939 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180747 | XAV 939 >98% | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545850 | XAV 939 >98% | 5mg | $146.2 | 2021-12-16 | Buy |
Properties
Boiling point :429.3±55.0 °C(Predicted)
Density :1.5
Flash point :213.4℃
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :0.23±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Density :1.5
Flash point :213.4℃
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :0.23±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. It is regulated through degradation of the downstream effector β-catenin via a complex consisting of the tumor suppressor APC, axin, and glycogen synthase kinase 3 (GSK3). Axin is the concentration-limiting factor for this degradation complex. Initially indentified as telomere-associated proteins, tankyrases promote axin ubiquitination, possibly through poly-ADP-ribosylation (PARsylation). XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 with IC50 values of 11 and 4 nM, respectively. By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells. At concentrations as low as 0.33 μM, XAV939 inhibits colony formation of APC-deficient colorectal cancer cells.More related product prices
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