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ChemicalBook >> CAS DataBase List >> Irinotecan hydrochloride

Irinotecan hydrochloride

Irinotecan hydrochloride price.
  • $25 - $2128
  • Product name: Irinotecan hydrochloride
  • CAS: 100286-90-6
  • MF: C33H39ClN4O6
  • MW: 623.15
  • EINECS:600-054-0
  • MDL Number:MFCD01862255
  • Synonyms:7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecinhydrochlor ;Irinotecan hydrochloride (S)-[1,4'-Bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride;(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-9-yl ester monohydrochloride trihydrate;Camptothecin 11;U 101440E;(S)-[1,4'-Bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride;[1,4’-Bipiperidine]-1’-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl Ester Hydrochloride Trihydrate;CTP-11
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Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • JR MediChem
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
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  • Usbiological
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  • 1g
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product numberJ53069
  • Product descriptionIrinotecan hydrochloride
  • Packaging5g
  • Price$2128
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60743
  • Product descriptionIrinotecan hydrochloride
  • Packaging50mg
  • Price$185.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60743
  • Product descriptionIrinotecan hydrochloride
  • Packaging250mg
  • Price$683.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62370
  • Product descriptionIrinotecan hydrochloride trihydrate, 99%
  • Packaging250mg
  • Price$693
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA309111
  • Product description(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+%
  • Packaging10mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA309111
  • Product description(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+%
  • Packaging50mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA309111
  • Product description(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+%
  • Packaging100mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA309111
  • Product description(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+%
  • Packaging250mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA309111
  • Product description(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+%
  • Packaging1g
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA309111
  • Product description(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+%
  • Packaging5g
  • Price$759
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS032537
  • Product descriptionIrinotecan hydrochloride ≥98%
  • Packaging10mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS032537
  • Product descriptionIrinotecan hydrochloride ≥98%
  • Packaging50mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS032537
  • Product descriptionIrinotecan hydrochloride ≥98%
  • Packaging100mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN90886
  • Product descriptionIrinotecan hydrochloride
  • Packaging20mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS032537
  • Product descriptionIrinotecan hydrochloride ≥98%
  • Packaging250mg
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS032537
  • Product descriptionIrinotecan hydrochloride ≥98%
  • Packaging1g
  • Price$163
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J53069 Irinotecan hydrochloride 5g $2128 2021-12-16 Buy
Alfa Aesar J60743 Irinotecan hydrochloride 50mg $185.65 2024-03-01 Buy
Alfa Aesar J60743 Irinotecan hydrochloride 250mg $683.65 2024-03-01 Buy
Alfa Aesar J62370 Irinotecan hydrochloride trihydrate, 99% 250mg $693 2021-12-16 Buy
Ambeed A309111 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+% 10mg $25 2021-12-16 Buy
Ambeed A309111 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+% 50mg $42 2021-12-16 Buy
Ambeed A309111 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+% 100mg $56 2021-12-16 Buy
Ambeed A309111 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+% 250mg $74 2021-12-16 Buy
Ambeed A309111 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+% 1g $165 2021-12-16 Buy
Ambeed A309111 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride 98+% 5g $759 2021-12-16 Buy
Arctom AS032537 Irinotecan hydrochloride ≥98% 10mg $25 2021-12-16 Buy
Arctom AS032537 Irinotecan hydrochloride ≥98% 50mg $42 2021-12-16 Buy
Arctom AS032537 Irinotecan hydrochloride ≥98% 100mg $55 2021-12-16 Buy
Arctom CFN90886 Irinotecan hydrochloride 20mg $60 2021-12-16 Buy
Arctom AS032537 Irinotecan hydrochloride ≥98% 250mg $73 2021-12-16 Buy
Arctom AS032537 Irinotecan hydrochloride ≥98% 1g $163 2021-12-16 Buy

Properties

Melting point :250-256°C (dec.)
Boiling point :257 °C
refractive index :67.7 ° (C=1, H2O)
storage temp. :2-8°C
solubility :Soluble in DMSO or DMF at approximately 20mg/ml. Sparingly soluble in aqueous buffers. /n
form :Yellow powder
color :White to yellow
Water Solubility :Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck :5091
CAS DataBase Reference :100286-90-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.

Description

Irinotecan, a derivative of the alkaloid camptothecin , functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1. Irinotecan demonstrates a broad spectrum of antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other solid tumors and has proven useful in radiation treatment of tumors by sensitizing tissue to radiation damage.

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