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ChemicalBook >> CAS DataBase List >> Shikonin

Shikonin

Shikonin price.
  • $11 - $2245.7
  • Product name: Shikonin
  • CAS: 517-89-5
  • MF: C16H16O5
  • MW: 288.3
  • EINECS:
  • MDL Number:MFCD00075680
  • Synonyms:5,8-Dihydroxy-2-[(R)-1-hydroxy-4-methyl-3-pentenyl]-1,4-naphthalenedione;Tokyo Violet;(R)-5,8-Dihydroxy-2-(1-hydroxy-4-Methylpent-3-en-1-yl)naphthalene-1,4-dione;SHIKONIN(AS);Shikonin, froM Arnebia sp.;(-)-ShikoninChina;Shikonine;Shikonin 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione
49 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Apolloscientific
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Labseeker
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
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  • 100mg
  • 250mg
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  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0487-M050
  • Product descriptionShikonin ≥98%(HPLC)
  • Packaging50mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberI664
  • Product descriptionShikonin
  • Packaging10mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberI664
  • Product descriptionShikonin
  • Packaging50mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA706788
  • Product description(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97%
  • Packaging1g
  • Price$530
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA706788
  • Product description(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97%
  • Packaging250mg
  • Price$201
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA706788
  • Product description(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97%
  • Packaging100mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA706788
  • Product description(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97%
  • Packaging50mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA706788
  • Product description(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97%
  • Packaging25mg
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA706788
  • Product description(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97%
  • Packaging10mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA706788
  • Product description(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97%
  • Packaging1mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0000036
  • Product descriptionSHIKONIN 95.00%
  • Packaging5MG
  • Price$429.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0000036
  • Product descriptionSHIKONIN 95.00%
  • Packaging10MG
  • Price$459
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0323
  • Product descriptionShikonin
  • Packaging100mg
  • Price$379
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0323
  • Product descriptionShikonin
  • Packaging50mg
  • Price$232
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBISN0323
  • Product descriptionShikonin
  • Packaging10mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN92622
  • Product descriptionShikonine ≥98%
  • Packaging20mg
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0487-M050 Shikonin ≥98%(HPLC) 50mg $160 2021-12-16 Buy
AK Scientific I664 Shikonin 10mg $67 2021-12-16 Buy
AK Scientific I664 Shikonin 50mg $188 2021-12-16 Buy
Ambeed A706788 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97% 1g $530 2021-12-16 Buy
Ambeed A706788 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97% 250mg $201 2021-12-16 Buy
Ambeed A706788 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97% 100mg $118 2021-12-16 Buy
Ambeed A706788 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97% 50mg $85 2021-12-16 Buy
Ambeed A706788 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97% 25mg $58 2021-12-16 Buy
Ambeed A706788 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97% 10mg $35 2021-12-16 Buy
Ambeed A706788 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 97% 1mg $11 2021-12-16 Buy
American Custom Chemicals Corporation PXT0000036 SHIKONIN 95.00% 5MG $429.5 2021-12-16 Buy
American Custom Chemicals Corporation PXT0000036 SHIKONIN 95.00% 10MG $459 2021-12-16 Buy
Apolloscientific BISN0323 Shikonin 100mg $379 2021-12-16 Buy
Apolloscientific BISN0323 Shikonin 50mg $232 2021-12-16 Buy
Apolloscientific BISN0323 Shikonin 10mg $77 2021-12-16 Buy
Arctom CFN92622 Shikonine ≥98% 20mg $70 2021-12-16 Buy

Properties

Melting point :148℃
Boiling point :567.4±50.0 °C(Predicted)
Density :1.373±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO : ≥ 31 mg/mL (107.53 mM);
pka :7.34±0.20(Predicted)
form :Red crystalline solid.
color :Brown
LogP :4.350 (est)
CAS DataBase Reference :517-89-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Shikonin is a naturally occurring naphthoquinine isolated from the dried root of L. erythrorhizon, an herb used in traditional Chinese medicine. It increases glucose uptake by adipocytes and myocytes and inhibits the activity of phosphatase and tensin homolog (PTEN; IC50 = 2.7 μM). It inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (IC50 = 0.3 μM). Shikonin induces cell death consistent with necroptosis in MCF-7 and HEK293 cancer cell lines. It inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication at nanomolar concentrations. Shikonin exhibits anti-inflammatory activity, reducing joint swelling and cartilage destruction in a mouse model of collagen-induced arthritis.

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