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ChemicalBook >> CAS DataBase List >> Leflunomide

Leflunomide

Leflunomide price.
  • $6 - $1504.5
  • Product name: Leflunomide
  • CAS: 75706-12-6
  • MF: C12H9F3N2O2
  • MW: 270.21
  • EINECS:616-254-6
  • MDL Number:MFCD00867593
  • Synonyms:LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE;5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide ;5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid
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  • AHH
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  • 10mM(in 1mL DMSO)
  • ManufacturerAHH
  • Product numberAPI-1149
  • Product descriptionLeflunomide 98%
  • Packaging10g
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH527
  • Product descriptionLeflunomide
  • Packaging100mg
  • Price$70
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberJ40005
  • Product descriptionLeflunomide
  • Packaging25mg
  • Price$76.5
  • Updated2021-12-16
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  • ManufacturerAlfa Aesar
  • Product numberJ65917
  • Product descriptionLeflunomide
  • Packaging500mg
  • Price$448.65
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ65917
  • Product descriptionLeflunomide
  • Packaging100mg
  • Price$143.65
  • Updated2024-03-01
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  • ManufacturerAmbeed
  • Product numberA133761
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA133761
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+%
  • Packaging50mg
  • Price$10
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA133761
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+%
  • Packaging100mg
  • Price$16
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA133761
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+%
  • Packaging250mg
  • Price$30
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA133761
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+%
  • Packaging1g
  • Price$76
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA133761
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+%
  • Packaging5g
  • Price$225
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA133761
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+%
  • Packaging25g
  • Price$516
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA2852
  • Product descriptionLeflunomide
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA2852
  • Product descriptionLeflunomide
  • Packaging100mg
  • Price$100
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS446068
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide ≥98%
  • Packaging25g
  • Price$511
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS446068
  • Product description5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide ≥98%
  • Packaging5g
  • Price$223
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1149 Leflunomide 98% 10g $660 2021-12-16 Buy
AK Scientific H527 Leflunomide 100mg $70 2021-12-16 Buy
AK Scientific J40005 Leflunomide 25mg $76.5 2021-12-16 Buy
Alfa Aesar J65917 Leflunomide 500mg $448.65 2024-03-01 Buy
Alfa Aesar J65917 Leflunomide 100mg $143.65 2024-03-01 Buy
Ambeed A133761 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+% 10mg $6 2021-12-16 Buy
Ambeed A133761 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+% 50mg $10 2021-12-16 Buy
Ambeed A133761 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+% 100mg $16 2021-12-16 Buy
Ambeed A133761 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+% 250mg $30 2021-12-16 Buy
Ambeed A133761 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+% 1g $76 2021-12-16 Buy
Ambeed A133761 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+% 5g $225 2021-12-16 Buy
Ambeed A133761 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide 98+% 25g $516 2021-12-16 Buy
ApexBio Technology A2852 Leflunomide 10mM(in 1mL DMSO) $80 2021-12-16 Buy
ApexBio Technology A2852 Leflunomide 100mg $100 2021-12-16 Buy
Arctom AS446068 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide ≥98% 25g $511 2021-12-16 Buy
Arctom AS446068 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide ≥98% 5g $223 2021-12-16 Buy

Properties

Melting point :166.5 °C
Boiling point :289.3±40.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Practically insoluble in water, freely soluble in methanol, sparingly soluble in methylene chloride.
form :Solid
pka :10.8(at 25℃)
color :White
Merck :14,5432
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :VHOGYURTWQBHIL-UHFFFAOYSA-N
CAS DataBase Reference :75706-12-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Leflunomide is a synthetic isoxazol derivative that regulates T lymphocyte progression through the cell cycle by selectively inhibiting de novo pyrimidine synthesis. As a prodrug, it is rapidly converted to its active open ring metabolite, A-771726 , which inhibits human lymphocyte proliferation with an IC50 value of 12.5 μM, in vitro. Leflunomide has been evaluated in phase II and III clinical trials for efficacy in slowing the disease progression of rheumatoid arthritis. It has also been used as an immunosuppressant agent to prevent rejection of transplant allografts and xenografts.

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