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ChemicalBook >> CAS DataBase List >> LY-3177833

LY-3177833

LY-3177833 price.
  • $55 - $1300
  • Product name: LY-3177833
  • CAS: 1627696-51-8
  • MF: C16H12FN5O
  • MW: 309.3
  • EINECS:-0
  • MDL Number:MFCD30533280
  • Synonyms:LY-3177833;(R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)isoindolin-1-one;LY 3177833;LY-3177833;CS-2783;1H-Isoindol-1-one, 3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-, (3R)-;LY3177833,CDK,Cyclin dependent kinase,Inhibitor,inhibit,LY 3177833
10 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number7406DY
  • Product descriptionCID81689696
  • Packaging50mg
  • Price$910
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25988
  • Product descriptionLY3177833 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25988
  • Product descriptionLY3177833 ≥98%
  • Packaging10mg
  • Price$166
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25988
  • Product descriptionLY3177833 ≥98%
  • Packaging25mg
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25988
  • Product descriptionLY3177833 ≥98%
  • Packaging50mg
  • Price$728
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6210
  • Product descriptionLY3177833 99.78%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00008484
  • Product descriptionLY-3177833 98+%
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00008484
  • Product descriptionLY-3177833 98+%
  • Packaging10mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00008484
  • Product descriptionLY-3177833 98+%
  • Packaging50mg
  • Price$277
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9766
  • Product descriptionLY3177833 >98%
  • Packaging250mg
  • Price$1300
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7406DY CID81689696 50mg $910 2021-12-16 Buy
Cayman Chemical 25988 LY3177833 ≥98% 5mg $93 2024-03-01 Buy
Cayman Chemical 25988 LY3177833 ≥98% 10mg $166 2024-03-01 Buy
Cayman Chemical 25988 LY3177833 ≥98% 25mg $388 2024-03-01 Buy
Cayman Chemical 25988 LY3177833 ≥98% 50mg $728 2024-03-01 Buy
ChemScene CS-6210 LY3177833 99.78% 5mg $120 2021-12-16 Buy
Crysdot CD00008484 LY-3177833 98+% 5mg $55 2021-12-16 Buy
Crysdot CD00008484 LY-3177833 98+% 10mg $97 2021-12-16 Buy
Crysdot CD00008484 LY-3177833 98+% 50mg $277 2021-12-16 Buy
DC Chemicals DC9766 LY3177833 >98% 250mg $1300 2021-12-16 Buy

Properties

Boiling point :660.7±55.0 °C(Predicted)
Density :1.398±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM)
form :A crystalline solid
pka :11.67±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P310 Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.

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