Hesperadin
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- $28 - $1802
- Product name: Hesperadin
- CAS: 422513-13-1
- MF: C29H32N4O3S
- MW: 516.65
- EINECS:200-258-5
- MDL Number:MFCD18074526
- Synonyms:(Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide;Hesperadin Hesperadine;N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]ethanesulfonamide Hesperadin;Hesperadin, >=98%;Hesperadin;Hesperadin hydrochloride;N-[(3Z)-2-Oxo-3-[phenyl-[4-(piperidin-1-ylMethyl)anilino]Methylidene]-1H-indol-5-yl]ethanesulfonaMide;Hesperadine
29 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 50
- 1unit
- 1mg
- 5MG
- 10mg
- 10
- 25mg
- 50mg
- 100mg
- 10mM(in 1mL DMSO)
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001425
- Product descriptionHESPERADIN HYDROCHLORIDE 99.00%
- Packaging5MG
- Price$495.68
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4118
- Product descriptionHesperadin
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4118
- Product descriptionHesperadin
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4118
- Product descriptionHesperadin
- Packaging10mM(in 1mL DMSO)
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4118
- Product descriptionHesperadin
- Packaging10mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60160
- Product descriptionHesperadin ≥98%
- Packaging10mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2096
- Product descriptionHesperadin 99%
- Packaging5mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146089
- Product descriptionHesperadin >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146089
- Product descriptionHesperadin >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146089
- Product descriptionHesperadin >98%
- Packaging1g
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number24199
- Product descriptionHesperadin ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24199
- Product descriptionHesperadin ≥98%
- Packaging5mg
- Price$202
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24199
- Product descriptionHesperadin ≥98%
- Packaging10mg
- Price$310
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24199
- Product descriptionHesperadin ≥98%
- Packaging25mg
- Price$711
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM148852
- Product description(Z)-N-(2-Oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulfonamide 95%+
- Packaging100mg
- Price$825
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0213
- Product descriptionHesperadin ≥98.0%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | KIN0001425 | HESPERADIN HYDROCHLORIDE 99.00% | 5MG | $495.68 | 2021-12-16 | Buy |
| ApexBio Technology | A4118 | Hesperadin | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4118 | Hesperadin | 5mg | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A4118 | Hesperadin | 10mM(in 1mL DMSO) | $105 | 2021-12-16 | Buy |
| ApexBio Technology | A4118 | Hesperadin | 10mg | $155 | 2021-12-16 | Buy |
| Arctom | CFN60160 | Hesperadin ≥98% | 10mg | $188 | 2021-12-16 | Buy |
| Axon Medchem | Axon2096 | Hesperadin 99% | 5mg | $104.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146089 | Hesperadin >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146089 | Hesperadin >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146089 | Hesperadin >98% | 1g | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 5mg | $202 | 2024-03-01 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 10mg | $310 | 2024-03-01 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 25mg | $711 | 2024-03-01 | Buy |
| Chemenu | CM148852 | (Z)-N-(2-Oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulfonamide 95%+ | 100mg | $825 | 2021-12-16 | Buy |
| ChemScene | CS-0213 | Hesperadin ≥98.0% | 5mg | $60 | 2021-12-16 | Buy |
Properties
Melting point :228 °C
Density :1.326
storage temp. :Refrigerator
solubility :DMSO, Methanol
form :Solid
pka :9.14±0.20(Predicted)
color :Yellow
CAS DataBase Reference :422513-13-1
Density :1.326
storage temp. :Refrigerator
solubility :DMSO, Methanol
form :Solid
pka :9.14±0.20(Predicted)
color :Yellow
CAS DataBase Reference :422513-13-1
Safety Information
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Description
Hesperadin is a multi-kinase inhibitor. It inhibits human Aurora kinase B (IC50 = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC50 = 40 nM) in in vitro kinase assays. Hesperadin (1 μM) inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases. It also inhibits MEKK2 in ATPase and transphosphorylation assays with IC50s of 60 and 34 nM, respectively. Hesperadin (50-100 nM) induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides mitotic arrest induced by paclitaxel or monastrol . Hesperadin also induces toxicity in HepG2 cells with a toxic concentration (TC50) value of less than 0.2 μM. It inhibits replication of clinical isolates of influenza A and B viruses with EC50s ranging from 0.22 to 2.21 μM in a plaque formation assay. Hesperadin inhibits the growth of T. brucei, L. major promastigotes and amastigotes, and P. falciparum with EC50 values ranging from 0.01 to 2.37 μM, but has less activity against T. cruzi (EC50 = 39 μM).Related product price
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