MK-5108 (VX-689)
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- $57 - $3728.1
- Product name: MK-5108 (VX-689)
- CAS: 1010085-13-8
- MF: C22H21ClFN3O3S
- MW: 461.94
- EINECS:
- MDL Number:MFCD22124479
- Synonyms:trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid;MK-5108(VX-689);(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylaMino)pyridin-2-yl)Methyl)cyclohexanecarboxylic acid;MK-5198;MK 5108; VX-689; VX 689; MK5108; VX689;CS-545;Cyclohexanecarboxylic acid, 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans-;MK-5108 (VX-689) USP/EP/BP
31 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 200mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberSYN5739
- Product descriptionMK-5108
- Packaging10mg
- Price$273
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4120
- Product descriptionMK-5108(VX-689)
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4120
- Product descriptionMK-5108(VX-689)
- Packaging10mM(in 1mL DMSO)
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4120
- Product descriptionMK-5108(VX-689)
- Packaging10mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4120
- Product descriptionMK-5108(VX-689)
- Packaging50mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4120
- Product descriptionMK-5108(VX-689)
- Packaging200mg
- Price$1350
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS009025
- Product descriptionMK-5108
- Packaging1mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60245
- Product descriptionMK-5108(VX-689) ≥98%
- Packaging10mg
- Price$408
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1961
- Product descriptionMK5108-VX689 98%
- Packaging5mg
- Price$121
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181290
- Product descriptionMK-5108 >98%
- Packaging100mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181290
- Product descriptionMK-5108 >98%
- Packaging250mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181290
- Product descriptionMK-5108 >98%
- Packaging1000mg
- Price$3728.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM103119
- Product descriptionMK 5108
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM103119
- Product descriptionMK 5108
- Packaging50mg
- Price$647.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19167
- Product descriptionMK-5108 ≥95%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19167
- Product descriptionMK-5108 ≥95%
- Packaging5mg
- Price$249
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5739 | MK-5108 | 10mg | $273 | 2021-12-16 | Buy |
| ApexBio Technology | A4120 | MK-5108(VX-689) | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A4120 | MK-5108(VX-689) | 10mM(in 1mL DMSO) | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A4120 | MK-5108(VX-689) | 10mg | $170 | 2021-12-16 | Buy |
| ApexBio Technology | A4120 | MK-5108(VX-689) | 50mg | $450 | 2021-12-16 | Buy |
| ApexBio Technology | A4120 | MK-5108(VX-689) | 200mg | $1350 | 2021-12-16 | Buy |
| Arctom | AS009025 | MK-5108 | 1mg | $72 | 2021-12-16 | Buy |
| Arctom | CFN60245 | MK-5108(VX-689) ≥98% | 10mg | $408 | 2021-12-16 | Buy |
| Axon Medchem | Axon1961 | MK5108-VX689 98% | 5mg | $121 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181290 | MK-5108 >98% | 100mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181290 | MK-5108 >98% | 250mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181290 | MK-5108 >98% | 1000mg | $3728.1 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM103119 | MK 5108 | 10mg | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM103119 | MK 5108 | 50mg | $647.5 | 2021-12-16 | Buy |
| Cayman Chemical | 19167 | MK-5108 ≥95% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 19167 | MK-5108 ≥95% | 5mg | $249 | 2024-03-01 | Buy |
Properties
Boiling point :637.6±65.0 °C(Predicted)
Density :1.429
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :4.41±0.44(Predicted)
color :White to off-white
Density :1.429
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :4.41±0.44(Predicted)
color :White to off-white
Safety Information
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Description
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM). It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types. It is effective in vivo, inhibiting the growth of xenograft tumors in mice.Related product price
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