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ChemicalBook >> CAS DataBase List >> GSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII price.
  • $44 - $927
  • Product name: GSK-3β Inhibitor XVIII
  • CAS: 1139875-74-3
  • MF: C20H20ClN5OS
  • MW: 413.92
  • EINECS:
  • MDL Number:MFCD32671859
  • Synonyms:GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;GSK3β-IN-1a;GSK3β Inhibitor XVIII;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-;GSK3β-IN-1a;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;GSK-3β inhibitor 8
6 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerAK Scientific
  • Product number3559DG
  • Product description(2-Chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone
  • Packaging25mg
  • Price$927
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21198
  • Product descriptionGSK3β Inhibitor XVIII
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21198
  • Product descriptionGSK3β Inhibitor XVIII
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21198
  • Product descriptionGSK3β Inhibitor XVIII
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21198
  • Product descriptionGSK3β Inhibitor XVIII
  • Packaging25mg
  • Price$745
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number361562
  • Product descriptionGSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
  • Packaging5mg
  • Price$238
  • Updated2023-01-07
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3559DG (2-Chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone 25mg $927 2021-12-16 Buy
Cayman Chemical 21198 GSK3β Inhibitor XVIII 1mg $44 2024-03-01 Buy
Cayman Chemical 21198 GSK3β Inhibitor XVIII 5mg $193 2024-03-01 Buy
Cayman Chemical 21198 GSK3β Inhibitor XVIII 10mg $341 2024-03-01 Buy
Cayman Chemical 21198 GSK3β Inhibitor XVIII 25mg $745 2024-03-01 Buy
Sigma-Aldrich 361562 GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem 5mg $238 2023-01-07 Buy

Properties

Boiling point :632.3±65.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble
pka :6?+-.0.10(Predicted)
form :White solid
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.