AZD5363
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- $45 - $2839
- Product name: AZD5363
- CAS: 1143532-39-1
- MF: C21H25ClN6O2
- MW: 428.92
- EINECS:
- MDL Number:MFCD22628785
- Synonyms:AZD5356;AZD5363;4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide;4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide AZD5363;AZD 5363 dihydrochloride;AZD5363;AZD-5363;AZD 5363;(S)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidi;AZD5363, 99%, a potent pan-AKT kinase inhibitor
28 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
- TRC
Package
- 2mg
- 5
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 250mg
- 25
- 1000mg
- 1g
- ManufacturerAK Scientific
- Product number2241AH
- Product descriptionAZD5363
- Packaging1mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1387
- Product descriptionAZD5363
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1387
- Product descriptionAZD5363
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1387
- Product descriptionAZD5363
- Packaging100mg
- Price$580
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60088
- Product descriptionCapivasertib(AZD5363)
- Packaging20mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181205
- Product descriptionAZD5363 >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181205
- Product descriptionAZD5363 >98%
- Packaging250mg
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181205
- Product descriptionAZD5363 >98%
- Packaging1000mg
- Price$2839
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA29493
- Product descriptionAZD 5363
- Packaging1mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA29493
- Product descriptionAZD 5363
- Packaging2mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA29493
- Product descriptionAZD 5363
- Packaging5mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA29493
- Product descriptionAZD 5363
- Packaging10mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA29493
- Product descriptionAZD 5363
- Packaging25mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15406
- Product descriptionAZD 5363 ≥98%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15406
- Product descriptionAZD 5363 ≥98%
- Packaging5mg
- Price$166
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15406
- Product descriptionAZD 5363 ≥98%
- Packaging10mg
- Price$231
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2241AH | AZD5363 | 1mg | $116 | 2021-12-16 | Buy |
| ApexBio Technology | A1387 | AZD5363 | 5mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A1387 | AZD5363 | 25mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | A1387 | AZD5363 | 100mg | $580 | 2021-12-16 | Buy |
| Arctom | CFN60088 | Capivasertib(AZD5363) | 20mg | $288 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181205 | AZD5363 >98% | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181205 | AZD5363 >98% | 250mg | $1504.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181205 | AZD5363 >98% | 1000mg | $2839 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA29493 | AZD 5363 | 1mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA29493 | AZD 5363 | 2mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA29493 | AZD 5363 | 5mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA29493 | AZD 5363 | 10mg | $350 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA29493 | AZD 5363 | 25mg | $550 | 2021-12-16 | Buy |
| Cayman Chemical | 15406 | AZD 5363 ≥98% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 15406 | AZD 5363 ≥98% | 5mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 15406 | AZD 5363 ≥98% | 10mg | $231 | 2024-03-01 | Buy |
Properties
Melting point :161-164°C
Density :1.381
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.93±0.50(Predicted)
form :Solid
color :Off-White to Pale Beige
Density :1.381
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.93±0.50(Predicted)
form :Solid
color :Off-White to Pale Beige
Safety Information
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Description
Akt functions as a key component in multiple signaling pathways including those related to cell proliferation, metabolism, and survival as well as angiogenesis. AZD 5363 is a pyrrolopyrimidine-derived compound that inhibits Akt by competitively binding to the kinase domain, preventing substrate phosphorylation by Akt. It inhibits Akt1, 2, and 3 with IC50 values of 3, 7, and 7 nM, respectively and also inhibits P70S6K and PKA with similar potency (IC50s = 6 and 7 nM, respectively). Furthermore, AZD 5363 shows >75% inhibition at 1 μM against ROCK-II, MKK1, MSK1, MSK2, PKCγ, PKGα, PKGβ, PRKX, RSK2, and RSK3. At 3 μM or less, AZD 5363 has been reported to inhibit the proliferation of 41 out of 182 solid and hematologic tumor cell lines, demonstrating the greatest sensitivity towards breast cancer derived-cells or those with PIK3CA and/or PTEN mutations. Oral dosing to nude mice bearing BT474c xenografts resulted in antitumor activity, including the reduction of the phosphorylation of PRAS40, GSK3β, and S6 at an EC50 value of ~ 0.1 μM.More related product prices
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