溴夫定
| 中文名稱 | 溴夫定 |
|---|---|
| 中文同義詞 | 溴夫定;溴乙烯尿苷;5-[(E)-2-溴乙烯基]-1-[(2R,4S,5R)-4-羥基-5-(羥甲基)氧雜環(huán)戊-2-基]嘧啶-2,4-二酮;溴呋啶;溴夫定(標(biāo)準(zhǔn)品);溴夫啶;(E)-5-(2-溴乙烯基)-2'-脫氧核苷;溴比夫定 |
| 英文名稱 | Brivudine |
| 英文同義詞 | Helpin;Uridine,5-[(1E)-2-broMoethenyl]-2'-deoxy-;(E)-(5)-BROMOVINYL-2-DEOXYURIDINE;(E)-5-(2-Bromovinyl)-2'-deoxyuridine;BVDU;(E)-5-(2-BROMOVINYL)-2'-DEOXY-URIDINE;BRIVUDINE;5-(E)-(2-Bromovinyl)-2-deoxyuridine |
| CAS號(hào) | 69304-47-8 |
| 分子式 | C11H13BrN2O5 |
| 分子量 | 333.14 |
| EINECS號(hào) | 1806241-263-5 |
| 相關(guān)類別 | 合成;醫(yī)藥原料藥;醫(yī)藥中間體;小分子抑制劑;小分子抑制劑，天然產(chǎn)物;其他科研原料藥;API;Inhibitors |
| Mol文件 | 69304-47-8.mol |
| 結(jié)構(gòu)式 |  |
溴夫定 性質(zhì)
| 熔點(diǎn) | 165°C |
|---|---|
| 密度 | 1.7800 (rough estimate) |
| 折射率 | 1.6520 (estimate) |
| 儲(chǔ)存條件 | Inert atmosphere,2-8°C |
| 溶解度 | 可溶于DMSO（少許）、甲醇（少許） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 8.37±0.10(Predicted) |
| 顏色 | 米白色 |
| 水溶解性 | Soluble in water and methanol. |
| Merck | 14,1378 |
| InChIKey | ODZBBRURCPAEIQ-CXYVBZRVSA-N |
Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.
At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia.
安全信息
| 安全說(shuō)明 | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS號(hào) | YU7355000 |
| 海關(guān)編碼 | 29349990 |
| 提供商 | 語(yǔ)言 |
|---|---|
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英文
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| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-13578 | 溴夫定 Brivudine | 69304-47-8 | 25mg | 350元 |
| 2025/02/08 | HY-13578 | 溴夫定 Brivudine | 69304-47-8 | 10mM * 1mLin DMSO | 385元 |