鹽酸益母草堿
中文名稱 | 鹽酸益母草堿 |
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中文同義詞 | 益母草堿鹽酸鹽,益母草堿;鹽酸益母草堿(益母草堿鹽酸鹽,益母草堿);LEONURINE HYDROCHLORIDE 鹽酸益母草堿;鹽酸益母草堿(3,5-二甲氧基-4-羥基-苯甲酸 (4-胍基)-1-丁酯一水合物鹽酸鹽);鹽酸益母草堿;3,5-二甲氧基-4-羥基-苯甲酸 (4-胍基)-1-丁酯一水合物鹽酸鹽;益母草堿鹽酸鹽;鹽酸益母草堿(標(biāo)準(zhǔn)品) |
英文名稱 | Leonurine hydrochloride |
英文同義詞 | Leonurine 4-Guanidino-1-butanol syringate;SCM-198;leonurine hydrochloride;4-Guanidino-1-butanol syringate;4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxy-benzoate hydrochloride;LEONURINE HCL;4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester;Syringic acid ζ-guanidinobutyl ester |
CAS號(hào) | 24697-74-3 |
分子式 | C14H21N3O5 |
分子量 | 311.33 |
EINECS號(hào) | 683-174-6 |
植物來(lái)源 | 益母草 |
相關(guān)類別 | 中草藥成分;中藥對(duì)照品;標(biāo)準(zhǔn)品;對(duì)照品,標(biāo)準(zhǔn)品;植物提取物;對(duì)照品;植提標(biāo)準(zhǔn)品;合成;醫(yī)藥原料藥;標(biāo)準(zhǔn)品-對(duì)照品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;對(duì)照品-中藥對(duì)照品;生物堿;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品,對(duì)照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;原料;醫(yī)藥化工類 |
Mol文件 | 24697-74-3.mol |
結(jié)構(gòu)式 | ![]() |
鹽酸益母草堿 性質(zhì)
熔點(diǎn) | 238 °C |
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沸點(diǎn) | 496.7±55.0 °C(Predicted) |
密度 | 1.29±0.1 g/cm3(Predicted) |
儲(chǔ)存條件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | DMSO:可溶,2mg/mL,澄清(加熱) |
酸度系數(shù)(pKa) | 8.26±0.25(Predicted) |
形態(tài) | 粉末 |
顏色 | 白色至米色 |
穩(wěn)定性 | 可在-20°C下的DMSO溶液保存長(zhǎng)達(dá)1個(gè)月。 |
InChIKey | WNGSUWLDMZFYNZ-UHFFFAOYSA-N |
Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24?h. Leonurine hydrochloride (125, 250, 500?μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20?μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.
Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.
藥理藥效:1.對(duì)子宮的作用益母草堿對(duì)兔、貓、犬、豚鼠等多種動(dòng)物的子宮均呈興奮作用2.對(duì)循環(huán)系統(tǒng)的作用小劑量益母草堿對(duì)離體蛙心有增強(qiáng)收縮作用,使用大量時(shí)反呈抑制現(xiàn)象。這種抑制現(xiàn)象可能由于迷走神經(jīng)末梢興奮所致。
更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
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2025/02/08 | HY-N0741A | 鹽酸益母草堿 Leonurine hydrochloride | 24697-74-3 | 10mM * 1mLin DMSO | 198元 |
2025/02/08 | HY-N0741A | 鹽酸益母草堿 Leonurine hydrochloride | 24697-74-3 | 5mg | 650元 |