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鹽酸益母草堿

鹽酸益母草堿

中文名稱鹽酸益母草堿
中文同義詞益母草堿鹽酸鹽,益母草堿;鹽酸益母草堿(益母草堿鹽酸鹽,益母草堿);LEONURINE HYDROCHLORIDE 鹽酸益母草堿;鹽酸益母草堿(3,5-二甲氧基-4-羥基-苯甲酸 (4-胍基)-1-丁酯一水合物鹽酸鹽);鹽酸益母草堿;3,5-二甲氧基-4-羥基-苯甲酸 (4-胍基)-1-丁酯一水合物鹽酸鹽;益母草堿鹽酸鹽;鹽酸益母草堿(標(biāo)準(zhǔn)品)
英文名稱Leonurine hydrochloride
英文同義詞Leonurine 4-Guanidino-1-butanol syringate;SCM-198;leonurine hydrochloride;4-Guanidino-1-butanol syringate;4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxy-benzoate hydrochloride;LEONURINE HCL;4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester;Syringic acid ζ-guanidinobutyl ester
CAS號(hào)24697-74-3
分子式C14H21N3O5
分子量311.33
EINECS號(hào)683-174-6
植物來(lái)源益母草
相關(guān)類別中草藥成分;中藥對(duì)照品;標(biāo)準(zhǔn)品;對(duì)照品,標(biāo)準(zhǔn)品;植物提取物;對(duì)照品;植提標(biāo)準(zhǔn)品;合成;醫(yī)藥原料藥;標(biāo)準(zhǔn)品-對(duì)照品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;對(duì)照品-中藥對(duì)照品;生物堿;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品,對(duì)照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;原料;醫(yī)藥化工類
Mol文件24697-74-3.mol
結(jié)構(gòu)式鹽酸益母草堿 結(jié)構(gòu)式

鹽酸益母草堿 性質(zhì)

熔點(diǎn)238 °C
沸點(diǎn)496.7±55.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度DMSO:可溶,2mg/mL,澄清(加熱)
酸度系數(shù)(pKa)8.26±0.25(Predicted)
形態(tài)粉末
顏色白色至米色
穩(wěn)定性可在-20°C下的DMSO溶液保存長(zhǎng)達(dá)1個(gè)月。
InChIKeyWNGSUWLDMZFYNZ-UHFFFAOYSA-N

鹽酸益母草堿 用途與合成方法

Leonurine 是從 Herba leonuri 中分離到的生物堿,具有抗氧化、抗炎活性。

Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24?h. Leonurine hydrochloride (125, 250, 500?μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20?μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.

化學(xué)性質(zhì) 
白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來(lái)源于益母草。
用途 
益母草堿具有活血、祛淤、調(diào)經(jīng)、消水的作用。
用途 
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等
藥理藥效:1.對(duì)子宮的作用益母草堿對(duì)兔、貓、犬、豚鼠等多種動(dòng)物的子宮均呈興奮作用2.對(duì)循環(huán)系統(tǒng)的作用小劑量益母草堿對(duì)離體蛙心有增強(qiáng)收縮作用,使用大量時(shí)反呈抑制現(xiàn)象。這種抑制現(xiàn)象可能由于迷走神經(jīng)末梢興奮所致。

安全信息

危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說(shuō)明26-24/25
WGK Germany3
海關(guān)編碼29399990

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/08HY-N0741A鹽酸益母草堿
Leonurine hydrochloride
24697-74-310mM * 1mLin DMSO198元
2025/02/08HY-N0741A鹽酸益母草堿
Leonurine hydrochloride
24697-74-35mg650元

鹽酸益母草堿 上下游產(chǎn)品信息

"鹽酸益母草堿"相關(guān)產(chǎn)品信息
4-氨基苯甲酸丁酯 鹽酸罌粟堿 甲胺基阿維菌素苯甲酸鹽 鹽酸小檗堿 偶氮氯磷 乙酸丁酯 油酸丁酯 氰氟草酯 尼泊金異丁酯 鹽酸拓?fù)涮婵?/a> 尼泊金丁酯 苯甲酸芐酯 噻嗪酮 二乙二醇丁醚 苯甲酸鈉 苯甲地那銨 胍基乙酸 益母草苷A 益母草堿
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