沒(méi)食子酸甲酯
| 中文名稱 | 沒(méi)食子酸甲酯 |
|---|---|
| 中文同義詞 | 沒(méi)食子酸甲酯;3,4,5-三羥基苯甲酸甲酯;3,4,5-三羥基苯甲酸甲酯,98%;電子級(jí)沒(méi)食子酸甲酯(99.9%,MG);3,4,5-三羥基苯甲酸甲酯酯/沒(méi)食子酸甲酯;棓酸甲酯,五棓子酸甲酯,3,4,5-三羥基苯甲酸甲酯;沒(méi)食子酸甲脂;3,4,5-三羥基苯甲酸甲酯, 98.0%(GC&T |
| 英文名稱 | Methyl gallate |
| 英文同義詞 | 3,4,5-trihydroxybenzoic acid methyl ester (intermediate of bifendate);METHYL GALLATE(METHYL 3,4,5-TRIHYDROXYBENZOATE );METHYLGALLATE(RG);2-diazo-1-naphthol-5-sulfonic acid, ester with novolac;METHYGALLATE;3,4,5-trihydroxy-benzoic acidd methyl ester;METHYL 3,4,5-TRIHYDROXYBENZOATE / METHYL GALLATE;Gallic acid methyl ester, Methyl 3,4,5-trihydroxybenzoate |
| CAS號(hào) | 99-24-1 |
| 分子式 | C8H8O5 |
| 分子量 | 184.15 |
| EINECS號(hào) | 202-741-7 |
| 相關(guān)類別 | 羰基化合物;中藥對(duì)照品;細(xì)胞生物學(xué);植物提取物;標(biāo)準(zhǔn)品;對(duì)照品;醫(yī)藥中間體;其他生化試劑;化學(xué)試劑;細(xì)胞信號(hào)和神經(jīng)生物學(xué);工業(yè)原料;生化試劑;分析試劑標(biāo)準(zhǔn)品;生化試劑-其他化學(xué)試劑;有機(jī)化工原料;化工;沒(méi)食子酸甲酯;其他原料;Photo Active Compounds;Aromatic Esters;Organic acids;(intermediate of bifendate);Food additive ,Antioxidant anticorrosive;化工原料;對(duì)照品-中藥對(duì)照品;其它酚類;化工原料-1827181813;有機(jī)中間體;化工中間體工業(yè)原料;標(biāo)準(zhǔn)品，對(duì)照品;精細(xì)化工原料;添加劑;有機(jī)化工原料;通用生化試劑-有機(jī)酸;香精香料 |
| Mol文件 | 99-24-1.mol |
| 結(jié)構(gòu)式 |  |
沒(méi)食子酸甲酯 性質(zhì)
| 熔點(diǎn) | 201-204 °C |
|---|---|
| 沸點(diǎn) | 278.08°C (rough estimate) |
| 密度 | 1.3840 (rough estimate) |
| 折射率 | 1.5690 (estimate) |
| 儲(chǔ)存條件 | Inert atmosphere,Room Temperature |
| 溶解度 | 乙醇：50 mg/mL，澄清 |
| 酸度系數(shù)(pKa) | 8.04±0.23(Predicted) |
| 形態(tài) | 結(jié)晶粉末 |
| 顏色 | 白色至略帶米色 |
| 水溶解性 | SOLUBLE IN HOT WATER |
| Merck | 14,4345 |
| BRN | 2113180 |
| InChIKey | FBSFWRHWHYMIOG-UHFFFAOYSA-N |
| LogP | 0.860 |
| CAS 數(shù)據(jù)庫(kù) | 99-24-1(CAS DataBase Reference) |
| EPA化學(xué)物質(zhì)信息 | Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1) |
沒(méi)食子酸甲酯通過(guò)抑制CD4+CD25+調(diào)節(jié)性T細(xì)胞的浸潤(rùn)表現(xiàn)出強(qiáng)大的抗腫瘤活性。
Methyl gallate是具有抗氧化，抗癌和抗炎活性的植物酚類。Methyl gallate也可抑制細(xì)菌活性。Methyl gallate 還具有抗 HIV-1 和 HIV-1 酶的抑制活性。Bacterial
The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H 2 O 2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H 2 O 2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
安全信息
| 危險(xiǎn)品標(biāo)志 | Xn,Xi |
|---|---|
| 危險(xiǎn)類別碼 | 22-36/37/38-43 |
| 安全說(shuō)明 | 26-36/37-24/25 |
| WGK Germany | 3 |
| RTECS號(hào) | LW8000000 |
| TSCA | Yes |
| 海關(guān)編碼 | 29182900 |
| 提供商 | 語(yǔ)言 |
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