坡模酸
| 中文名稱 | 坡模酸 |
|---|---|
| 中文同義詞 | 坡模醇酸;坡模酸;坡模醇酸,坡模酸;蘭地酸A;(1R,2R,4AS,6AS,6BR,8AR,10S,12AR,12BR,14BS)-1,10-二羥基-1,2,6A,6B,9,9,12A-七甲基-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-十八氫 苉-4A(2H)-羧酸 |
| 英文名稱 | POMOLIC ACID |
| 英文同義詞 | POMOLIC ACID;3β,19-Dihydroxy-5α-urs-12-en-28-oic acid;3β,19-Dihydroxyurs-12-en-28-oic acid;3β,19α-Dihydroxyurs-12-ene-28-oic acid;Benthamic acid;Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3β)-;Randialic acid A;(1R,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-1,10-Dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid |
| CAS號(hào) | 13849-91-7 |
| 分子式 | C30H48O4 |
| 分子量 | 472.7 |
| EINECS號(hào) | |
| 相關(guān)類別 | 對(duì)照品;中藥對(duì)照品;對(duì)照品;三萜;標(biāo)準(zhǔn)品，對(duì)照品;Triterpenoids;Miscellaneous Natural Products |
| Mol文件 | 13849-91-7.mol |
| 結(jié)構(gòu)式 |  |
坡模酸 性質(zhì)
| 熔點(diǎn) | 297-299 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) |
|---|---|
| 沸點(diǎn) | 586.2±50.0 °C(Predicted) |
| 密度 | 1.14±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 4°C, protect from light |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 4.48±0.70(Predicted) |
| 顏色 | 白色至米白色 |
Randialic acid A (Pomolic acid) 是一種五環(huán)三萜烯，是從 Euscaphis japonica 中分離出來(lái)的。Randialic acid A (Pomolic acid) 抑制腫瘤細(xì)胞的生長(zhǎng)并誘導(dǎo)細(xì)胞凋亡。 Randialic acid A (Pomolic acid) 有用于前列腺癌的潛力。
IC50: apoptosis
Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation. ?Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-N6601 | Pomolic acid | 1 mg | 1400元 | |
| 2024/11/08 | HY-N6601 | 坡模酸 Pomolic acid | 13849-91-7 | 5mg | 3700元 |