PF-01367338
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- $28 - $8373.75
- Product name: PF-01367338
- CAS: 459868-92-9
- MF: C19H21FN3O5P
- MW: 421.37
- EINECS:-0
- MDL Number:MFCD17010269
- Synonyms:AG-014699;AG-014699;PF-01367338;PF-01367338;AG14699;8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate;Rucaparib (AG-014699 , PF-01367338);Rucaparib phosphate;AG-014699 (Rucaparib)
44 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 10mM(in 1mL DMSO)
- 1unit
- 2MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 5g
- ManufacturerAK Scientific
- Product numberSYN5566
- Product descriptionAG014699
- Packaging50mg
- Price$547
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424427
- Product description8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+%
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424427
- Product description8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+%
- Packaging10mg
- Price$194
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424427
- Product description8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+%
- Packaging25mg
- Price$291
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424427
- Product description8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+%
- Packaging50mg
- Price$407
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424427
- Product description8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+%
- Packaging100mg
- Price$571
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424427
- Product description8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+%
- Packaging250mg
- Price$911
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000926
- Product descriptionAG-014699 95.00%
- Packaging2MG
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000926
- Product descriptionAG-014699 95.00%
- Packaging25MG
- Price$8373.75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4156
- Product descriptionRucaparib(AG-014699,PF-01367338)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4156
- Product descriptionRucaparib(AG-014699,PF-01367338)
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4156
- Product descriptionRucaparib(AG-014699,PF-01367338)
- Packaging10mM(in 1mL DMSO)
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4156
- Product descriptionRucaparib(AG-014699,PF-01367338)
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4156
- Product descriptionRucaparib(AG-014699,PF-01367338)
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4156
- Product descriptionRucaparib(AG-014699,PF-01367338)
- Packaging200mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60165
- Product descriptionRucaparib(AG-014699)phosphate ≥98%
- Packaging10mg
- Price$238
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5566 | AG014699 | 50mg | $547 | 2021-12-16 | Buy |
| Ambeed | A424427 | 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+% | 5mg | $130 | 2021-12-16 | Buy |
| Ambeed | A424427 | 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+% | 10mg | $194 | 2021-12-16 | Buy |
| Ambeed | A424427 | 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+% | 25mg | $291 | 2021-12-16 | Buy |
| Ambeed | A424427 | 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+% | 50mg | $407 | 2021-12-16 | Buy |
| Ambeed | A424427 | 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+% | 100mg | $571 | 2021-12-16 | Buy |
| Ambeed | A424427 | 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate 99+% | 250mg | $911 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000926 | AG-014699 95.00% | 2MG | $540 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000926 | AG-014699 95.00% | 25MG | $8373.75 | 2021-12-16 | Buy |
| ApexBio Technology | A4156 | Rucaparib(AG-014699,PF-01367338) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4156 | Rucaparib(AG-014699,PF-01367338) | 5mg | $75 | 2021-12-16 | Buy |
| ApexBio Technology | A4156 | Rucaparib(AG-014699,PF-01367338) | 10mM(in 1mL DMSO) | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A4156 | Rucaparib(AG-014699,PF-01367338) | 10mg | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A4156 | Rucaparib(AG-014699,PF-01367338) | 50mg | $350 | 2021-12-16 | Buy |
| ApexBio Technology | A4156 | Rucaparib(AG-014699,PF-01367338) | 200mg | $850 | 2021-12-16 | Buy |
| Arctom | CFN60165 | Rucaparib(AG-014699)phosphate ≥98% | 10mg | $238 | 2021-12-16 | Buy |
Properties
Melting point :>173°C (dec.)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Yellow solid.
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Yellow solid.
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||
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Description
Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is used as a therapeutic strategy to selectively target cancers. Rucaparib is a potent, cell-permeable inhibitor of PARP-1 (Ki = <5 nM) that is used in clinical therapy to sensitize cancer cells to chemotherapy. Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM. At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors. It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts. Rucaparib (phosphate) is the phosphate salt of rucaparib and has improved aqueous solubility.More related product prices
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