TIQ-A
|
- $32 - $1732.5
- Product name: TIQ-A
- CAS: 420849-22-5
- MF: C11H7NOS
- MW: 201.24
- EINECS:
- MDL Number:MFCD06407947
- Synonyms:Thieno[2,3-c]isoquinolin-5(4H)-one;TIQ-A,poly ADP ribose polymerase,ADP-ribosyltransferase,TIQA,Inhibitor,PARP,TIQ A,inhibit,tankyrases,ADP-ribosylation,poly-ART
12 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 50MG
- ManufacturerAK Scientific
- Product number3747BB
- Product description4H-Thieno[2,3-c]isoquinolin-5-one
- Packaging1mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3747BB
- Product description4H-Thieno[2,3-c]isoquinolin-5-one
- Packaging5mg
- Price$353
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001037
- Product descriptionTIQ-A 95.00%
- Packaging1MG
- Price$160.65
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001037
- Product descriptionTIQ-A 95.00%
- Packaging5MG
- Price$756.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001037
- Product descriptionTIQ-A 95.00%
- Packaging50MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging500μg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging5mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging10mg
- Price$396
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberT2825
- Product descriptionTIQ-A ≥98% (HPLC), solid
- Packaging5mg
- Price$365
- Updated2022-05-15
- Buy
- ManufacturerSigma-Aldrich
- Product numberT2825
- Product descriptionTIQ-A ≥98% (HPLC), solid
- Packaging1mg
- Price$109
- Updated2022-05-15
- Buy
- ManufacturerTRC
- Product numberT445100
- Product descriptionTIQ-A
- Packaging1mg
- Price$45
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3747BB | 4H-Thieno[2,3-c]isoquinolin-5-one | 1mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 3747BB | 4H-Thieno[2,3-c]isoquinolin-5-one | 5mg | $353 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001037 | TIQ-A 95.00% | 1MG | $160.65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001037 | TIQ-A 95.00% | 5MG | $756.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001037 | TIQ-A 95.00% | 50MG | $1732.5 | 2021-12-16 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 5mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 10mg | $396 | 2024-03-01 | Buy |
| Sigma-Aldrich | T2825 | TIQ-A ≥98% (HPLC), solid | 5mg | $365 | 2022-05-15 | Buy |
| Sigma-Aldrich | T2825 | TIQ-A ≥98% (HPLC), solid | 1mg | $109 | 2022-05-15 | Buy |
| TRC | T445100 | TIQ-A | 1mg | $45 | 2021-12-16 | Buy |
Properties
Melting point :256-258°C
Boiling point :282.2±9.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
pka :13.04±0.20(Predicted)
form :solid
color :Light green to green
Boiling point :282.2±9.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
pka :13.04±0.20(Predicted)
form :solid
color :Light green to green
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis. TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons). It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 μM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.Related product price
- NU1025
$31-1053 - 3-Aminobenzamide
$5-1800 - 4-AMINO-1,8-NAPHTHALIMIDE
$44-1022.42
Suppliers and manufacturers
Career Henan Chemica Co
TargetMol Chemicals Inc.
J & K SCIENTIFIC LTD.
Chemsky（shanghai）International Co.,Ltd.
BOC Sciences
Shanghai EFE Biological Technology Co., Ltd.
Shanghai Hongye Biotechnology Co. Ltd
Shenzhen Polymeri Biochemical Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Taizhou Nanfeng Pharmaceutical Research Institute