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106266-06-2
???:
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???(??):
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Risperidone
???(??):
RISPERDAL;RISPERIDAL;Risperdal Consta;Risperidone(Risperdal);3-[2-4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one, R-64766, Belivon, Risperdal;Spiron;R-64766;BELIVON;CS-2004;Rispadal
CBNumber:
CB9131730
???:
C23H27FN4O2
??? ??:
410.48
MOL ??:
106266-06-2.mol
MSDS ??:
SDS

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???
170°C
?? ?
572.4±60.0 °C(Predicted)
??
1.38±0.1 g/cm3(Predicted)
???
9℃
?? ??
2-8°C
???
DMSO: ≥5mg/mL
?? ?? (pKa)
pKa 8.3 (Uncertain)
??? ??
??
??
???? ?????
???
44.74mg/L(25℃)
Merck
14,8233
BCS Class
2
CAS ??????
106266-06-2(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T,F
?? ???? ?? 25-39/23/24/25-23/24/25-11
????? 28-36-45-36/37-16
????(UN No.) 3249
WGK ?? 3
RTECS ?? UV1164800
?? ?? 6.1(a)
???? II
HS ?? 29333990
?? ?? ??? 106266-06-2(Hazardous Substances Data)
?? LD50 in male, female mice, rats, dogs (mg/kg): 29.7, 26.9, 34.3, 35.4, 14.1, 18.3 i.v.; 82.1, 63.1, 113, 56.6, 18.3, 18.3 orally (Janssen, 1988)
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
??????:
P301+P310 ???? ?? ????(??)? ??? ????.
NFPA 704
0
4 0

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Risperidone is a novel antipsychotic introduced for the treatment of acute and chronic schizophrenia. It has a balanced serotonin 5-HT2 and dopamine D2 receptor antagonist activity. While the anti-D2 activity may relate to the antipsychotic potency of neuroleptic agents, an antidepressive efficacy of substances with anti-5-HT2 activity has been suggested. Risperidone, therefore, has therapeutic action on both positive and negative symptoms of schizophrenia and produces significantly fewer side effects especially extrapyramidal symptoms compared with commonly used pure D2 antagonist antipsychotics. It also has potential for management of alcohol withdrawal and cocaine addiction.

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Crystalline Solid

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Risperidone has been used:

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ChEBI: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

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Risperidone (Risperdal, a benzisoxazole)has the structural features of a hybrid molecule between abutyrophenone antipsychotic and a trazodone-like antidepressant.Its superior side effects profile (compared withhaloperidol) at dosage of 6 mg/d or less and the lower riskof tardive dyskinesia have contributed to its very widespreaduse. It benefited refractory psychotic patients, withparkinsonism controlled at one tenth the dose of antiparkinsoniandrugs used with haloperidol.Coexisting anxietyand depressive syndromes were also lessened. It is reportedto decrease the negative (e.g., withdrawal, apathy) as well asthe positive (e.g., delusions, hallucinations) symptoms ofschizophrenia. This is reportedly a consequence of the compound’scombination 5-HT2–D2 receptor antagonistic properties.Overall, the reasons for the decreased EPS and effectiveness against negative symptom are still under investigation.It is an important atypical antipsychotic.Risperidone is metabolized in the liver by CYP2D6 to anactive metabolite, 9-hydroxyrisperidone. Because thismetabolite and risperidone are nearly equipotent, the clinicalefficacy of the drug reflects both compounds.

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Atypical antipsychotic agent that displays 5-HT 2A receptor antagonism. Also displays high affinity at D 2 receptors (K i values are 0.4 and 3.13 nM for 5-HT 2A and D 2 receptors respectively).

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???

???? ?? ????? 4-Pyrimidinol ???????(1,3-) 885706-66-1 ????????B 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one ?????E-?? 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime 2,4-???????-(4-?????)???????? 6-????-3-(4-?????)-1,2-?????? ?????????

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??????-1,4-????

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