?????????
|
|
????????? ??
- ???
- 210-213 °C(lit.)
- ?? ?
- 340-355 °C(Press: 0.5 Torr)
- ??
- 1.420±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- ???: 10mg/mL, ??, ??
- ?? ?? (pKa)
- 6.50±0.20(Predicted)
- ??? ??
- ??
- ??
- ???? ?????
- ???
- ?(25°C?? <1mg/ml), ?????, ???, DMSO(25°C?? 57mg/ml) ? ???(25°C?? 9mg/ml)? ?????.
- ?? ??(λmax)
- 263nm(EtOH)(lit.)
- BRN
- 278107
- LogP
- 3.341 (est)
- CAS ??????
- 491-80-5(CAS DataBase Reference)
????????? C??? ??, ??, ??
??
Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein , another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 μM).??? ??
Off-White Solid??
An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene?? ??
Biochanin A (BCA) is synthesized in vitro from phloroglucinol. A series of steps involving Friedel?Crafts reaction results in an intermediate product 1-(2,4,6-trihydroxyphenyl)-2-(4 methoxyphenyl) ethanone, which post cyclization leads to BCA. It is catabolized to isoflavone genistein post ingestion.????????? ?? ?? ? ???
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?? ??
????????? ?? ??
???( 395)?? ??
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