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Tizanidine

Tizanidine Struktur
51322-75-9
CAS-Nr.
51322-75-9
Englisch Name:
Tizanidine
Synonyma:
AB-021;C07452;TERNELIN;SIRDALUD;ZANAFLEX;DS-103-282;TIZANIDINE;TIZANIDINE HCL;Tizanidine USP/EP/BP;TIZANIDINE HCL 2% GRANULES
CBNumber:
CB9670538
Summenformel:
C9H8ClN5S
Molgewicht:
253.71
MOL-Datei:
51322-75-9.mol

Tizanidine Eigenschaften

Schmelzpunkt:
221-223°
Siedepunkt:
391.2±52.0 °C(Predicted)
Dichte
1.82±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
H2O: ~29 mg/mL
Aggregatzustand
solid
pka
7.48±0.10(Predicted)
Farbe
white
CAS Datenbank
51322-75-9(CAS DataBase Reference)
NIST chemische Informationen
Tizanidine(51322-75-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36/37/38
S-S?tze: 26-36
WGK Germany  3
RTECS-Nr. DK9910000
Toxizit?t LD50 orally in mice: 235 mg/kg (Sayers)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Tizanidine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Tizanidine is a centrally-acting muscle relaxant useful in the treatment of muscle spasms and a variety of spastic conditions.

Verwenden

Labeled Tizanidine, intended for use as an internal standard for the quantification of Tizanidine by GC- or LC-mass spectrometry.

Definition

ChEBI: 2,1,3-Benzothiadiazole substituted at C-4 by a Delta1-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.

Mechanism of action

Tizanidine is a centrally active muscle relaxant analogue of clonidine that is approved for use in reducing spasticity associated with cerebral or spinal cord injury. Its mechanism of action for reducing spasticity suggests presynaptic inhibition of motor neurons at the α2-adrenergic receptor sites, reducing the release of excitatory amino acids and inhibiting facilitatory ceruleospinal pathways, thus resulting in a reduction in spasticity. Tizanidine only has a small fraction of the antihypertensive action of clonidine, presumably because of action at a selective subgroup of α2C-adrenoceptors, which appear to be responsible for the analgesic and antispasmodic activity of imidazoline α2-agonists(20).

Clinical Use

Tizanidine is a centrally acting adrenergic α2 receptor agonist used to treat chronic muscle spasticity conditions, such as multiple sclerosis.

Nebenwirkungen

Postulated mechanisms include α2 receptor-mediated decreased release of norepinephrine and serotonin from spinal interneurons. Tizanidine is structurally related to the α2 agonist clonidine that is used to treat hypertension; however, the blood pressure–lowering potency of tizanidine is approximately 10 to 20% that of clonidine. Nevertheless, patients may experience hypotension with tizanidine, together with muscle weakness, that may result in dizziness and falls in mobile patients. Tizanidine is rapidly and almost completely absorbed from the gastrointestinal tract; however, the estimated bioavailability is only 10 to 15% because of extensive first-pass metabolism, mainly by CYP1A2, which results in oxidative degradation of the imidazoline ring and hydroxylation of the aromatic system. Elevated liver enzyme values are not frequent with tizanidine use. Hepatic injury and death because of liver failure have been reported, however, and this complication should be considered in view of its marginal antispasmodic efficacy. Other frequently reported side effects of tizanidine are drowsiness and dry mouth. Clonidine also has been used to treat spasticity; however, even less high-quality clinical study data are available for this agent.

Tizanidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tizanidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 136)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
+8617731987558
xingjiu@xingjiubiotech.com China 989 58
sgtlifesciences pvt ltd
+8617013299288
dj@sgtlifesciences.com China 12373 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896
cbc@coresyn.com China 9984 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58

51322-75-9()Verwandte Suche:


  • 3-benzothiadiazole,5-chloro-4-(2-imidazolin-2-ylamino)-1
  • 3-benzothiadiazole-4-amine,5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-1
  • 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
  • 5-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOLE-4-AMINE HYDROCHLORIDE
  • 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3-benzothiadiazole-4-amine
  • (5-CHLORO-BENZO[1,2,5]THIADIAZOL-4-YL)-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-AMINE
  • AB-021
  • DS-103-282
  • SIRDALUD
  • TERNELIN
  • TIZANIDINE
  • TIZANIDINE HCL
  • 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-8-thia-7,9-diazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine
  • ZANAFLEX
  • 5-Chloro-4-(2-imidazolin-2-ylamino)benzo-2,1,3-thiadiazole
  • 5-CHLORO-N-(4,5-DIHYDR-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOLE-4-AMINE
  • 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
  • 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-
  • 2,1,3-Benzothiadiazole-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-
  • C07452
  • 2,1,3-Benzothiadiazol-4-aMine, 5-chloro-N-(4,5-dihydro-1H-iMidazol-2-yl)-
  • 5-chloro-N-(4,5-dihydro-1H-iMidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-aMine hydrochloride
  • Tizanidine USP/EP/BP
  • TizanidineQ: What is Tizanidine Q: What is the CAS Number of Tizanidine Q: What is the storage condition of Tizanidine Q: What are the applications of Tizanidine
  • TIZANIDINE HCL 2% GRANULES
  • 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-amine
  • 51322-75-9
  • C9H8ClN5S
  • C9H8CIN5SHCI
  • Tizanidine
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